• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

甲状腺激素受体的单体、同二聚体及可能的异二聚体形式的差异性DNA结合

Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor.

作者信息

Lazar M A, Berrodin T J, Harding H P

机构信息

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104.

出版信息

Mol Cell Biol. 1991 Oct;11(10):5005-15. doi: 10.1128/mcb.11.10.5005-5015.1991.

DOI:10.1128/mcb.11.10.5005-5015.1991
PMID:1922030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC361489/
Abstract

Binding of the thyroid hormone receptor (TR) to thyroid hormone-responsive elements (TREs) is crucial for regulation of gene expression by thyroid hormone. The TR binds to each half-site of a palindromic TRE separately, as a monomer, or simultaneously, as a homodimer. In addition, the TR monomer interacts with a 42-kDa protein that may be responsible for an increase in the apparent size and stability of the TR-TRE complex after incubation with liver nuclear extract. The multiple DNA-binding forms of the TR contact the TRE differently but compete for binding in a dynamic equilibrium which is highly dependent on the relative concentrations of TR and nuclear protein. Thus, protein-protein interactions are likely to determine the context in which the TR binds to target genes and regulates the transcriptional response to thyroid hormone.

摘要

甲状腺激素受体（TR）与甲状腺激素反应元件（TREs）的结合对于甲状腺激素调节基因表达至关重要。TR作为单体分别与回文TRE的每个半位点结合，或作为同二聚体同时结合。此外，TR单体与一种42 kDa的蛋白质相互作用，该蛋白质可能是导致与肝核提取物孵育后TR-TRE复合物表观大小和稳定性增加的原因。TR的多种DNA结合形式与TRE的接触方式不同，但在高度依赖于TR和核蛋白相对浓度的动态平衡中竞争结合。因此，蛋白质-蛋白质相互作用可能决定TR与靶基因结合并调节对甲状腺激素转录反应的环境。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/1aefbcb77258/molcellb00034-0218-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/d1ee6f33f8e3/molcellb00034-0213-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/f6ae2b8e4346/molcellb00034-0214-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/d4b3c6023edb/molcellb00034-0214-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/1e7d30d92f23/molcellb00034-0215-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/decae61936a0/molcellb00034-0216-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/642ce9fb740e/molcellb00034-0217-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/4d9e42cdcd77/molcellb00034-0217-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/1aefbcb77258/molcellb00034-0218-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/d1ee6f33f8e3/molcellb00034-0213-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/f6ae2b8e4346/molcellb00034-0214-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/d4b3c6023edb/molcellb00034-0214-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/1e7d30d92f23/molcellb00034-0215-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/decae61936a0/molcellb00034-0216-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/642ce9fb740e/molcellb00034-0217-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/4d9e42cdcd77/molcellb00034-0217-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b5c/361489/1aefbcb77258/molcellb00034-0218-a.jpg

相似文献

1
Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor.甲状腺激素受体的单体、同二聚体及可能的异二聚体形式的差异性DNA结合
Mol Cell Biol. 1991 Oct;11(10):5005-15. doi: 10.1128/mcb.11.10.5005-5015.1991.
2
Structural features of thyroid hormone response elements that increase susceptibility to inhibition by an RTH mutant thyroid hormone receptor.甲状腺激素反应元件的结构特征增加了对RTH突变型甲状腺激素受体抑制作用的敏感性。
Endocrinology. 1996 Jul;137(7):2833-41. doi: 10.1210/endo.137.7.8770904.
3
Half-site arrangement of hybrid glucocorticoid and thyroid hormone response elements specifies thyroid hormone receptor complex binding to DNA and transcriptional activity.混合糖皮质激素和甲状腺激素反应元件的半位点排列决定了甲状腺激素受体复合物与DNA的结合及转录活性。
J Biol Chem. 1994 Apr 29;269(17):12704-9.
4
Differential binding and activation of thyroid hormone response elements by TR alpha 1 and RXR alpha-trap heterodimers.TRα1与RXRα陷阱异二聚体对甲状腺激素反应元件的差异结合与激活。
Mol Cell Endocrinol. 1994 Jun;102(1-2):111-7. doi: 10.1016/0303-7207(94)90104-x.
5
Discrimination of DNA response elements for thyroid hormone and estrogen is dependent on dimerization of receptor DNA binding domains.甲状腺激素和雌激素的DNA反应元件的区分取决于受体DNA结合结构域的二聚化。
Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5527-31. doi: 10.1073/pnas.89.12.5527.
6
Thyroid hormone receptor monomer, homodimer, and heterodimer (with retinoid-X receptor) contact different nucleotide sequences in thyroid hormone response elements.甲状腺激素受体单体、同二聚体和异二聚体（与视黄酸X受体形成）与甲状腺激素反应元件中的不同核苷酸序列结合。
Endocrinology. 1994 Oct;135(4):1628-38. doi: 10.1210/endo.135.4.7925126.
7
Thyroid hormone alters the DNA binding properties of chicken thyroid hormone receptors alpha and beta.甲状腺激素会改变鸡甲状腺激素受体α和β的DNA结合特性。
Nucleic Acids Res. 1992 Sep 25;20(18):4803-10. doi: 10.1093/nar/20.18.4803.
8
Characterization of the thyroid hormone response element in the skeletal alpha-actin gene: negative regulation of T3 receptor binding by the retinoid X receptor.骨骼肌α-肌动蛋白基因中甲状腺激素反应元件的特性：维甲酸X受体对T3受体结合的负调控
Cell Growth Differ. 1993 Apr;4(4):269-79.
9
Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific.突变型甲状腺激素受体的显性负抑制作用具有甲状腺激素反应元件和受体亚型特异性。
Mol Endocrinol. 1993 Oct;7(10):1319-30. doi: 10.1210/mend.7.10.8264663.
10
Transcriptional silencing by unliganded thyroid hormone receptor beta requires a soluble corepressor that interacts with the ligand-binding domain of the receptor.未结合配体的甲状腺激素受体β介导的转录沉默需要一种可溶性共抑制因子，该因子与受体的配体结合结构域相互作用。
Mol Cell Biol. 1996 May;16(5):1909-20. doi: 10.1128/MCB.16.5.1909.

引用本文的文献

1
Effects of Thyroid Hormones on Lipid Metabolism Pathologies in Non-Alcoholic Fatty Liver Disease.甲状腺激素对非酒精性脂肪性肝病脂质代谢病理的影响。
Biomedicines. 2022 May 25;10(6):1232. doi: 10.3390/biomedicines10061232.
2
Nuclear hormone receptors in demyelinating diseases.脱髓鞘疾病中的核激素受体。
J Neuroendocrinol. 2022 Jul;34(7):e13171. doi: 10.1111/jne.13171. Epub 2022 Jun 22.
3
The Role of Estrogen and Thyroid Hormones in Zebrafish Visual System Function.雌激素和甲状腺激素在斑马鱼视觉系统功能中的作用

本文引用的文献

1
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.从分离的哺乳动物细胞核的可溶性提取物中，RNA聚合酶II进行准确的转录起始。
Nucleic Acids Res. 1983 Mar 11;11(5):1475-89. doi: 10.1093/nar/11.5.1475.
2
Limited capacity binding sites for L-triiodothyronine in rat liver nuclei. Localization to the chromatin and partial characterization of the L-triiodothyronine-chromatin complex.大鼠肝细胞核中L-三碘甲状腺原氨酸的有限容量结合位点。L-三碘甲状腺原氨酸-染色质复合物在染色质中的定位及部分特性研究。
J Biol Chem. 1973 Oct 25;248(20):7066-72.
3
The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements.
Front Pharmacol. 2022 Feb 28;13:837687. doi: 10.3389/fphar.2022.837687. eCollection 2022.
4
Subcellular Distribution of Thyroid Hormone Receptor Beta in Ovarian Cancer.甲状腺激素受体β在卵巢癌中的亚细胞分布。
Int J Mol Sci. 2022 Feb 28;23(5):2698. doi: 10.3390/ijms23052698.
5
Thyroid hormone receptor phosphorylation regulates acute fasting-induced suppression of the hypothalamic-pituitary-thyroid axis.甲状腺激素受体磷酸化调节急性禁食诱导的下丘脑-垂体-甲状腺轴抑制。
Proc Natl Acad Sci U S A. 2021 Sep 28;118(39). doi: 10.1073/pnas.2107943118.
6
A New Mechanism in THRA Resistance: The First Disease-Associated Variant Leading to an Increased Inhibitory Function of THRA2.甲状腺激素受体α（THRA）抵抗的一种新机制：首个与疾病相关的导致THRA2抑制功能增强的变体
Int J Mol Sci. 2021 May 19;22(10):5338. doi: 10.3390/ijms22105338.
7
Hormonal Regulation of Oligodendrogenesis I: Effects across the Lifespan.激素对少突胶质细胞发生的调节 I：全生命周期的影响。
Biomolecules. 2021 Feb 14;11(2):283. doi: 10.3390/biom11020283.
8
A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver.在肝脏中，甲状腺激素的作用依赖于核心调节因子的转变，而非经典的开关。
Genes Dev. 2021 Mar 1;35(5-6):367-378. doi: 10.1101/gad.345686.120. Epub 2021 Feb 18.
9
Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease.核受体与非酒精性脂肪性肝病的转录调控。
Mol Metab. 2021 Aug;50:101119. doi: 10.1016/j.molmet.2020.101119. Epub 2020 Nov 18.
10
Genomic and Non-Genomic Mechanisms of Action of Thyroid Hormones and Their Catabolite 3,5-Diiodo-L-Thyronine in Mammals.甲状腺激素及其代谢产物 3,5-二碘-L-甲状腺原氨酸在哺乳动物中的基因组和非基因组作用机制。
Int J Mol Sci. 2020 Jun 10;21(11):4140. doi: 10.3390/ijms21114140.
甲状腺激素受体与甲状腺激素和雌激素反应元件中的一个共同序列基序结合，产生相反的转录效应。
Cell. 1988 Jul 29;54(3):313-23. doi: 10.1016/0092-8674(88)90194-8.
4
The steroid and thyroid hormone receptor superfamily.类固醇和甲状腺激素受体超家族。
Science. 1988 May 13;240(4854):889-95. doi: 10.1126/science.3283939.
5
Regulation of gene expression by thyroid hormone.甲状腺激素对基因表达的调控。
J Clin Invest. 1988 Apr;81(4):957-67. doi: 10.1172/JCI113449.
6
The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer.雌激素受体作为配体诱导的同源二聚体与它的反应元件紧密结合。
Cell. 1988 Oct 7;55(1):145-56. doi: 10.1016/0092-8674(88)90017-7.
7
c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities.c-Jun 与自身以及 c-Fos 形成二聚体，形成具有不同 DNA 结合亲和力的复合物。
Cell. 1988 Dec 2;55(5):917-24. doi: 10.1016/0092-8674(88)90147-x.
8
DNA binding activities of three murine Jun proteins: stimulation by Fos.三种小鼠Jun蛋白的DNA结合活性：Fos的刺激作用
Cell. 1988 Dec 2;55(5):907-15. doi: 10.1016/0092-8674(88)90146-8.
9
fos-associated cellular p39 is related to nuclear transcription factor AP-1.与fos相关的细胞p39与核转录因子AP-1有关。
Cell. 1988 Aug 12;54(4):553-60. doi: 10.1016/0092-8674(88)90077-3.
10
The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes.c-Fos蛋白与c-Jun/AP-1相互作用，以刺激AP-1反应基因的转录。
Cell. 1988 Aug 12;54(4):541-52. doi: 10.1016/0092-8674(88)90076-1.