从一种上皮细胞系中克隆出一个生长停滞特异性且受转化生长因子β调节的基因TI 1。
Cloning of a growth arrest-specific and transforming growth factor beta-regulated gene, TI 1, from an epithelial cell line.
作者信息
Kallin B, de Martin R, Etzold T, Sorrentino V, Philipson L
机构信息
European Molecular Biology Laboratory, Heidelberg, Germany.
出版信息
Mol Cell Biol. 1991 Oct;11(10):5338-45. doi: 10.1128/mcb.11.10.5338-5345.1991.
Abstract
By cDNA cloning and differential screening, five genes that are regulated by transforming growth factor beta (TGF beta) in mink lung epithelial cells were identified. A novel membrane protein gene, TI 1, was identified which was downregulated by TGF beta and serum in quiescent cells. In actively growing cells, the TI 1 gene is rapidly and transiently induced by TGF beta, and it is overexpressed in the presence of protein synthesis inhibitors. It appears to be related to a family of transmembrane glycoproteins that are expressed on lymphocytes and tumor cells. The four other genes were all induced by TGF beta and correspond to the genes of collagen alpha type I, fibronectin, plasminogen activator inhibitor 1, and the monocyte chemotactic cell-activating factor (JE gene) previously shown to be TGF beta regulated.
摘要
通过cDNA克隆和差异筛选，在貂肺上皮细胞中鉴定出五个受转化生长因子β（TGFβ）调控的基因。鉴定出一个新的膜蛋白基因TI 1，在静止细胞中它受TGFβ和血清的下调。在活跃生长的细胞中，TI 1基因被TGFβ快速短暂诱导，并且在存在蛋白质合成抑制剂的情况下会过度表达。它似乎与在淋巴细胞和肿瘤细胞上表达的跨膜糖蛋白家族有关。其他四个基因均由TGFβ诱导，分别对应于I型胶原α、纤连蛋白、纤溶酶原激活物抑制剂1以及先前已证明受TGFβ调控的单核细胞趋化细胞激活因子（JE基因）的基因。
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