Rollins B J, Morrison E D, Stiles C D
Division of Medicine, Harvard Medical School, Boston, MA.
Proc Natl Acad Sci U S A. 1988 Jun;85(11):3738-42. doi: 10.1073/pnas.85.11.3738.
The platelet-derived growth factor-inducible gene JE has been widely used as a molecular marker for the cellular response to growth factors, antimitogenic agents, and other biological response modifiers; however, the structure of the JE gene and the nature of its encoded protein have not been previously described. We present here structural and regulatory features of the JE gene and its product that link it to a family of cytokines, including macrophage colony-stimulating factor, interferon alpha, interleukin 6 (also known as interferon beta 2, B-cell-stimulatory factor 2, 26-kDa protein, and hybridoma/plasmacytoma growth factor), and interleukin 2. Just as T lymphocytes secrete interleukins as a component of their response to mitogens, it appears that fibroblasts secrete cytokines as a component of their response to platelet-derived growth factor.
血小板衍生生长因子诱导基因JE已被广泛用作细胞对生长因子、抗有丝分裂剂及其他生物反应调节剂反应的分子标志物；然而，JE基因的结构及其编码蛋白的性质此前尚未见报道。我们在此展示JE基因及其产物的结构和调控特征，这些特征将其与一类细胞因子联系起来，包括巨噬细胞集落刺激因子、α干扰素、白细胞介素6（也称为β2干扰素、B细胞刺激因子2、26 kDa蛋白及杂交瘤/浆细胞瘤生长因子）和白细胞介素2。正如T淋巴细胞分泌白细胞介素作为其对有丝分裂原反应的一部分一样，成纤维细胞似乎也分泌细胞因子作为其对血小板衍生生长因子反应的一部分。
