是“会说话的基因”还是“用于说话的基因”？解读言语和语言的遗传学奥秘。
Speaking genes or genes for speaking? Deciphering the genetics of speech and language.
作者信息
Grigorenko Elena L
机构信息
Yale University, Child Study Center, 230 South Frontage Road, New Haven, CT 06519-1124, USA.
出版信息
J Child Psychol Psychiatry. 2009 Jan;50(1-2):116-25. doi: 10.1111/j.1469-7610.2008.02006.x.
Abstract
BACKGROUND
This article selectively reviews the status of the genetic research in the field of speech and language disorders.
METHODS
Major contributions to the field are selected, presented, and discussed.
RESULTS
The field presents itself through a variety of findings, characterized by both consistencies and inconsistencies.
CONCLUSIONS
The last 30 + years of the field unequivocally testify to the importance of genetic factors in the acquisition of speech and language. However, the details of how these factors exert their influence are yet to be determined.
摘要
背景
本文选择性地综述了言语和语言障碍领域的遗传学研究现状。
方法
选取、展示并讨论了该领域的主要研究成果。
结果
该领域呈现出各种各样的研究结果，既有一致性，也有不一致性。
结论
该领域过去30多年的研究明确证明了遗传因素在言语和语言习得中的重要性。然而，这些因素如何发挥作用的具体细节尚待确定。
相似文献
1
Speaking genes or genes for speaking? Deciphering the genetics of speech and language.是“会说话的基因”还是“用于说话的基因”？解读言语和语言的遗传学奥秘。
J Child Psychol Psychiatry. 2009 Jan;50(1-2):116-25. doi: 10.1111/j.1469-7610.2008.02006.x.
2
Genetic advances in the study of speech and language disorders.遗传在言语和语言障碍研究中的进展。
Neuron. 2010 Oct 21;68(2):309-20. doi: 10.1016/j.neuron.2010.10.001.
3
[Genetic factors in the development of language].[语言发展中的遗传因素]
Rev Neurol. 2010 Mar 3;50 Suppl 3:S101-6.
4
The genetics of speech and language impairments.言语和语言障碍的遗传学
N Engl J Med. 2008 Nov 27;359(22):2381-3. doi: 10.1056/NEJMe0807813. Epub 2008 Nov 5.
5
Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain.人类与言语和阅读相关的基因在狨猴大脑中表现出部分重叠的表达模式。
Brain Lang. 2014 Jun;133:26-38. doi: 10.1016/j.bandl.2014.03.007. Epub 2014 Apr 24.
6
[Speech disorders in children of aphasic fathers- a developmental psycholinguistic case study].
Prax Kinderpsychol Kinderpsychiatr. 1980 Apr;29(3):83-9.
7
Deciphering the genetic basis of speech and language disorders.解读言语和语言障碍的遗传基础。
Annu Rev Neurosci. 2003;26:57-80. doi: 10.1146/annurev.neuro.26.041002.131144. Epub 2003 Jan 8.
8
The role of candidate-gene CNTNAP2 in childhood apraxia of speech and specific language impairment.候选基因CNTNAP2在儿童言语失用症和特定语言障碍中的作用。
Am J Med Genet B Neuropsychiatr Genet. 2015 Oct;168(7):536-43. doi: 10.1002/ajmg.b.32325. Epub 2015 Jun 19.
9
Cntnap2 expression in the cerebellum of Foxp2(R552H) mice, with a mutation related to speech-language disorder.Foxp2(R552H) 基因突变相关的言语障碍小鼠小脑Cntnap2 的表达。
Neurosci Lett. 2012 Jan 11;506(2):277-80. doi: 10.1016/j.neulet.2011.11.022. Epub 2011 Nov 22.
10
Specific syndromes and associated communication disorders: a review.
J Commun Disord. 1984 Nov;17(6):385-405. doi: 10.1016/0021-9924(84)90002-9.
引用本文的文献
1
Population-based genetic effects for developmental stuttering.发育性口吃的群体遗传效应。
HGG Adv. 2021 Dec 2;3(1):100073. doi: 10.1016/j.xhgg.2021.100073. eCollection 2022 Jan 13.
2
Reintroducing Dyslexia: Early Identification and Implications for Pediatric Practice.重新认识诵读困难：早期识别与儿科实践的意义。
Pediatrics. 2020 Jul;146(1). doi: 10.1542/peds.2019-3046. Epub 2020 Jun 23.
3
How Young Children Learn Language and Speech.幼儿如何学习语言和言语。
Pediatr Rev. 2019 Aug;40(8):398-411. doi: 10.1542/pir.2017-0325.
4
Structural brain abnormalities in a single gene disorder associated with epilepsy, language impairment and intellectual disability.与癫痫、语言障碍和智力残疾相关的单基因疾病中的大脑结构异常。
Neuroimage Clin. 2016 Aug 4;12:655-665. doi: 10.1016/j.nicl.2016.07.016. eCollection 2016.
5
Cognitive, Linguistic, and Motor Abilities in a Multigenerational Family with Childhood Apraxia of Speech.一个患有儿童言语失用症的多代家庭中的认知、语言和运动能力
Arch Clin Neuropsychol. 2016 Dec 1;31(8):1006-1025. doi: 10.1093/arclin/acw077.
6
White Matter Alterations in Infants at Risk for Developmental Dyslexia.发育性阅读障碍高危婴儿的白质改变
Cereb Cortex. 2017 Feb 1;27(2):1027-1036. doi: 10.1093/cercor/bhv281.
7
Interaction effect between handedness and CNTNAP2 polymorphism (rs7794745 genotype) on voice-specific frontotemporal activity in healthy individuals: an fMRI study.健康个体中利手与CNTNAP2基因多态性（rs7794745基因型）对语音特异性额颞叶活动的交互作用：一项功能磁共振成像研究
Front Behav Neurosci. 2015 Apr 20;9:87. doi: 10.3389/fnbeh.2015.00087. eCollection 2015.
8
KIAA0319 and ROBO1: evidence on association with reading and pleiotropic effects on language and mathematics abilities in developmental dyslexia.KIAA0319与ROBO1：发育性阅读障碍中与阅读的关联及对语言和数学能力的多效性证据
J Hum Genet. 2014 Apr;59(4):189-97. doi: 10.1038/jhg.2013.141. Epub 2014 Jan 16.
9
Use of dysmorphology for subgroup classification on autism spectrum disorder in Chinese children.运用畸形学对中国儿童自闭症谱系障碍进行亚组分类。
J Autism Dev Disord. 2014 Jan;44(1):9-18. doi: 10.1007/s10803-013-1846-3.
10
Using brain imaging to unravel the mysteries of stuttering.利用脑成像技术揭开口吃之谜。
Cerebrum. 2011 Jul;2011:12. Epub 2011 Aug 23.
本文引用的文献
1
Generation of mice with a conditional Foxp2 null allele.具有条件性Foxp2无效等位基因的小鼠的产生。
Genesis. 2007 Jul;45(7):440-6. doi: 10.1002/dvg.20305.
2
Twins' Early Development Study (TEDS): a multivariate, longitudinal genetic investigation of language, cognition and behavior problems from childhood through adolescence.双胞胎早期发育研究（TEDS）：一项从童年到青春期对语言、认知和行为问题进行的多变量纵向基因调查。
Twin Res Hum Genet. 2007 Feb;10(1):96-105. doi: 10.1375/twin.10.1.96.
3
Multivariate linkage analysis of specific language impairment (SLI).特定语言障碍（SLI）的多变量连锁分析。
Ann Hum Genet. 2007 Sep;71(Pt 5):660-73. doi: 10.1111/j.1469-1809.2007.00361.x. Epub 2007 Mar 27.
4
Genes, language development, and language disorders.基因、语言发展与语言障碍。
Ment Retard Dev Disabil Res Rev. 2007;13(1):96-105. doi: 10.1002/mrdd.20135.
5
Genetic studies of stuttering in a founder population.奠基者群体中口吃的遗传学研究。
J Fluency Disord. 2007;32(1):33-50. doi: 10.1016/j.jfludis.2006.12.002. Epub 2006 Dec 30.
6
Heritable risk factors associated with language impairments.与语言障碍相关的遗传风险因素。
Genes Brain Behav. 2007 Feb;6(1):66-76. doi: 10.1111/j.1601-183X.2006.00232.x.
7
Further evidence of pleiotropy influencing speech and language: analysis of the DYX8 region.影响言语和语言的多效性的进一步证据：DYX8区域分析
Hum Hered. 2007;63(1):47-58. doi: 10.1159/000098727. Epub 2007 Jan 17.
8
Children's history of speech-language difficulties: genetic influences and associations with reading-related measures.儿童言语语言困难史：遗传影响及其与阅读相关指标的关联
J Speech Lang Hear Res. 2006 Dec;49(6):1280-93. doi: 10.1044/1092-4388(2006/092).
9
Singing mice, songbirds, and more: models for FOXP2 function and dysfunction in human speech and language.唱歌的小鼠、鸣禽等等：人类言语和语言中FOXP2功能与功能障碍的模型。
J Neurosci. 2006 Oct 11;26(41):10376-9. doi: 10.1523/JNEUROSCI.3379-06.2006.
10
Speech sound disorder influenced by a locus in 15q14 region.受15q14区域一个位点影响的语音障碍。
Behav Genet. 2006 Nov;36(6):858-68. doi: 10.1007/s10519-006-9090-7. Epub 2006 Jun 20.
Zotero 插件