胰岛素对麻醉兔肝脏中糖原分解级联反应及糖原合酶活性的影响。
The effect of insulin on the glycogenolytic cascade and on the activity of glycogen synthase in the liver of anaesthetized rabbits.
作者信息
van de Werve G, Stalmans W, Hers H G
出版信息
Biochem J. 1977 Jan 15;162(1):143-6. doi: 10.1042/bj1620143.
Abstract
- The administration of insulin to anaesthetized rabbits caused the inactivation of liver phosphorylase and phosphorylase kinase, but did not change either the hepatic concentration of cyclic AMP or the activity of cyclic AMP-dependent histone kinase. All measured parameters were increased by the subsequent administration of glucagon. 2. Activation of glycogen synthase by insulin was only observed when phosphorylase had been strongly inactivated.
摘要
- 给麻醉的兔子注射胰岛素会导致肝磷酸化酶和磷酸化酶激酶失活，但不会改变肝脏中环磷酸腺苷（cAMP）的浓度或cAMP依赖性组蛋白激酶的活性。随后注射胰高血糖素会使所有测量参数增加。2. 仅当磷酸化酶被强烈失活时，才观察到胰岛素对糖原合酶的激活作用。
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本文引用的文献
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