da Mata A D S P, da Silva Marques D N, Silveira J M L, Marques J R O F, de Melo Campos Felino E T, Guilherme N F R P M
Faculdade de Medicina, Dentária da Universidade de Lisboa, Lisbon, Portugal.
Oral Dis. 2009 Apr;15(3):220-8. doi: 10.1111/j.1601-0825.2009.01513.x. Epub 2009 Feb 8.
To compare salivary pH changes and stimulation efficacy of two different gustatory stimulants of salivary secretion (GSSS).
Portuguese Dental Faculty Clinic.
Double blind randomized controlled trial.
One hundred and twenty volunteers were randomized to two intervention groups. Sample sized was calculated using an alpha error of 0.05 and a beta of 0.20.
Participants were randomly assigned to receive a new gustatory stimulant of secretory secretion containing a weaker malic acid, fluoride and xylitol or a traditionally citric acid-based one. Saliva collection was obtained by established methods at different times. The salivary pH of the samples was determined with a pH meter and a microelectrode.
Salivary pH variations and counts of subjects with pH below 5.5 for over 1 min and stimulated salivary flow were the main outcome measures.
Both GSSS significantly stimulated salivary output without significant differences between the two groups. The new gustatory stimulant of salivary secretion presented a risk reduction of 80 +/- 10.6% (95% CI) when compared with the traditional one.
Gustatory stimulants of salivary secretion with fluoride, xylitol and lower acid content maintain similar salivary stimulation capacity while reducing significantly the dental erosion predictive potential.
比较两种不同的唾液分泌味觉刺激剂（GSSS）的唾液pH变化和刺激效果。
葡萄牙牙科学院诊所。
双盲随机对照试验。
120名志愿者被随机分为两个干预组。样本量使用0.05的α错误率和0.20的β错误率计算得出。
参与者被随机分配接受一种含有较弱苹果酸、氟化物和木糖醇的新型唾液分泌味觉刺激剂，或传统的基于柠檬酸的刺激剂。通过既定方法在不同时间收集唾液。用pH计和微电极测定样本的唾液pH值。
唾液pH变化、pH值低于5.5持续超过1分钟的受试者数量以及刺激唾液流量是主要观察指标。
两种GSSS均显著刺激唾液分泌，两组之间无显著差异。与传统刺激剂相比，新型唾液分泌味觉刺激剂的风险降低了80±10.6%（95%置信区间）。
含氟化物、木糖醇且酸含量较低的唾液分泌味觉刺激剂在保持相似唾液刺激能力的同时，显著降低了牙齿侵蚀的预测可能性。
