哺乳动物代谢循环的逻辑：振荡的NAD⁺/NADH氧化还原信号调节组蛋白的协同表达和S期进程。
Logic of a mammalian metabolic cycle: an oscillated NAD+/NADH redox signaling regulates coordinated histone expression and S-phase progression.
作者信息
Yu Fa-Xing, Dai Ru-Ping, Goh Shuang-Ru, Zheng Lei, Luo Yan
机构信息
Institute of Molecular and Cell Biology, Singapore, Singapore.
出版信息
Cell Cycle. 2009 Mar 1;8(5):773-9. doi: 10.4161/cc.8.5.7880. Epub 2009 Mar 18.
Abstract
Many biological activities naturally oscillate. Here, we show that the NAD(+)/NADH ratios (redox status) fluctuate during mammalian cell cycle, with the S-phase redox status being the least oxidative. The S-phase NAD(+)/NADH redox status gates histone expression and S-phase progression, and may provide a genome protection mechanism during S-phase DNA replication as implicated in yeast. Accordingly, perturbing the cellular redox inhibits histone expression and leads to S-phase arrest. We propose that the S-phase NAD(+)/NADH redox status constitutes a redox signaling, which along with the cyclin E/cdk2 signaling regulates histone expression and S-phase progression.
摘要
许多生物活动自然地呈周期性变化。在此，我们表明，在哺乳动物细胞周期中，NAD(+)/NADH比率（氧化还原状态）会发生波动，其中S期的氧化还原状态氧化性最低。S期的NAD(+)/NADH氧化还原状态控制组蛋白表达和S期进程，并且可能如在酵母中所涉及的那样，在S期DNA复制过程中提供一种基因组保护机制。因此，干扰细胞氧化还原会抑制组蛋白表达并导致S期停滞。我们提出，S期的NAD(+)/NADH氧化还原状态构成一种氧化还原信号，其与细胞周期蛋白E/细胞周期蛋白依赖性激酶2信号一起调节组蛋白表达和S期进程。
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