Zhou Maosong, Xie Hongfu, Cheng Lin, Li Ji
Maosong Zhou, Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Hongfu Xie, Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Pak J Med Sci. 2016 Nov-Dec;32(6):1344-1348. doi: 10.12669/pjms.326.11236.
To evaluate the clinical characteristics and epidermal barrier function of papulopustular rosacea by comparing with acne vulgaris.
Four hundred and sixty-three papulopustular rosacea patients and four hundred and twelve acne vulgaris patients were selected for the study in Xiangya Hospital of Central South University from March 2015 to May 2016. They were analyzed for major facial lesions, self-conscious symptoms and epidermal barrier function.
Erythema, burning, dryness and itching presented in papulopustular rosacea patients were significantly higher than that in acne vulgaris patients (<0.001). The clinical scores of erythema, burning, dryness and itching in papulopustular rosacea patients were significantly higher than those in acne vulgaris patients (<0.001). The water content of the stratum cornuem and skin surface lipid level were both significantly lower in papulopustular rosacea patients than that of the acne vulgaris patients (<0.001) and healthy subjects (<0.001); Water content of the stratum cornuem and skin surface lipid level were higher in acne vulgaris patients in comparison with that of healthy subjects (>0.05, <0.001; respectively). Transepidermal water loss was significantly higher in papulopustular rosacea patients than that of acne vulgaris patients and healthy subjects (<0.001); transepidermal water loss was lower in skin of acne vulgaris patients than that of healthy subjects (<0.001).
Erythema, burning, dryness and itching are the characteristics of papulopustular rosacea, which makes it different from acne vulgaris. The epidermal barrier function was damaged in papulopustular rosacea patients while not impaired in that of acne vulgaris patients.
通过与寻常痤疮比较，评估丘疹脓疱型酒渣鼻的临床特征及表皮屏障功能。
选取2015年3月至2016年5月在中南大学湘雅医院就诊的463例丘疹脓疱型酒渣鼻患者和412例寻常痤疮患者进行研究。分析其主要面部皮损、自觉症状及表皮屏障功能。
丘疹脓疱型酒渣鼻患者的红斑、灼热、干燥和瘙痒症状显著高于寻常痤疮患者（<0.001）。丘疹脓疱型酒渣鼻患者红斑、灼热、干燥和瘙痒的临床评分显著高于寻常痤疮患者（<0.001）。丘疹脓疱型酒渣鼻患者的角质层含水量和皮肤表面脂质水平均显著低于寻常痤疮患者（<0.001）及健康受试者（<0.001）；寻常痤疮患者的角质层含水量和皮肤表面脂质水平高于健康受试者（分别为>0.05，<0.001）。丘疹脓疱型酒渣鼻患者的经表皮水分流失显著高于寻常痤疮患者和健康受试者（<0.001）；寻常痤疮患者皮肤的经表皮水分流失低于健康受试者（<0.001）。
红斑、灼热、干燥和瘙痒是丘疹脓疱型酒渣鼻的特征，使其有别于寻常痤疮。丘疹脓疱型酒渣鼻患者的表皮屏障功能受损，而寻常痤疮患者未受损。
