Barrionuevo M, Campos M S, López Aliaga I, Coves F, Lisbona F
Department of Animal Physiology, Faculty of Pharmacy, University of Granada, Spain.
Int J Vitam Nutr Res. 1989;59(3):255-61.
The effects of intestinal resection and diet on the digestive and metabolic utilization of phosphorus were studied in adult rats from which 50% of the distal small intestine had been removed and in sham-operated controls. Metabolic parameters were measured both 1 and 3 months after surgery. The loss of half of the distal small intestine led to a decline in digestive utilization of phosphorus 1 month after surgery as reflected in bone mineral content. Digestive efficiency had improved by 3 months after surgery. One month's feeding with a diet in which fat was provided as equal parts of medium chain triglycerides, sunflower seed oil and olive oil instead of 100% olive oil enhanced phosphorus absorption and retention, although this improvement was less evident after 3 months. The negative effects of distal small intestine resection on the nutritive utilization of phosphorus were not only palliated but significantly enhanced by supplementing the diet with vitamin D3 at a rate of 0.08 mg/100 g diet. This dose is within physiological limits, and favors phosphorus deposition in bone tissue.
研究了肠道切除和饮食对成年大鼠磷的消化和代谢利用的影响，这些大鼠的远端小肠被切除了50%，并设置了假手术对照组。在手术后1个月和3个月测量代谢参数。术后1个月，远端小肠切除一半导致磷的消化利用率下降，这反映在骨矿物质含量上。术后3个月消化效率有所提高。用一种饮食喂养1个月，其中脂肪由中链甘油三酯、向日葵籽油和橄榄油等量提供，而不是100%橄榄油，可提高磷的吸收和保留，尽管3个月后这种改善不太明显。以0.08 mg/100 g饮食的剂量补充维生素D3，不仅减轻了远端小肠切除对磷营养利用的负面影响，而且显著增强了这种影响。该剂量在生理范围内，有利于磷在骨组织中的沉积。
