大分子过程的结构动力学
The structural dynamics of macromolecular processes.
作者信息
Russel Daniel, Lasker Keren, Phillips Jeremy, Schneidman-Duhovny Dina, Velázquez-Muriel Javier A, Sali Andrej
机构信息
Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, 1700 4th Street, San Francisco, CA 94158-2330, USA.
出版信息
Curr Opin Cell Biol. 2009 Feb;21(1):97-108. doi: 10.1016/j.ceb.2009.01.022. Epub 2009 Feb 14.
Abstract
Dynamic processes involving macromolecular complexes are essential to cell function. These processes take place over a wide variety of length scales from nanometers to micrometers, and over time scales from nanoseconds to minutes. As a result, information from a variety of different experimental and computational approaches is required. We review the relevant sources of information and introduce a framework for integrating the data to produce representations of dynamic processes.
摘要
涉及大分子复合物的动态过程对细胞功能至关重要。这些过程发生在从纳米到微米的各种长度尺度上，以及从纳秒到分钟的时间尺度上。因此，需要来自各种不同实验和计算方法的信息。我们回顾了相关的信息来源，并介绍了一个整合数据以生成动态过程表示的框架。
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