Traczewski Maria M, Katz Bradley D, Steenbergen Judith N, Brown Steven D
Clinical Microbiology Institute, 9725 SW Commerce Circle, Suite A-1, Wilsonville, OR 97070, USA.
Antimicrob Agents Chemother. 2009 May;53(5):1735-8. doi: 10.1128/AAC.01022-08. Epub 2009 Feb 17.
The inhibitory and bactericidal activities of daptomycin, vancomycin, and teicoplanin against a collection of 479 methicillin-resistant Staphylococcus aureus isolates were assessed. The isolates were collected from U.S. and European hospitals from 1985 to 2007 and were primarily from blood and abscess cultures. The MICs and minimum bactericidal concentrations (MBCs) of the three agents were determined, and the MBC/MIC ratios were calculated to determine the presence or absence of tolerance. Tolerance was defined as an MBC/MIC ratio of > or = 32 or an MBC/MIC ratio of > or = 16 when the MBC was greater than or equal to the breakpoint for resistance. Tolerance to vancomycin and teicoplanin was observed in 6.1% and 18.8% of the strains, respectively. Tolerance to daptomycin was not observed.
评估了达托霉素、万古霉素和替考拉宁对479株耐甲氧西林金黄色葡萄球菌分离株的抑制和杀菌活性。这些分离株于1985年至2007年从美国和欧洲医院收集,主要来自血液和脓肿培养物。测定了这三种药物的最低抑菌浓度(MIC)和最低杀菌浓度(MBC),并计算MBC/MIC比值以确定是否存在耐受性。耐受性定义为MBC/MIC比值≥32,或当MBC大于或等于耐药折点时MBC/MIC比值≥16。分别在6.1%和18.8%的菌株中观察到对万古霉素和替考拉宁的耐受性。未观察到对达托霉素的耐受性。