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本文引用的文献

1
Daptomycin bactericidal activity and correlation between disk and broth microdilution method results in testing of Staphylococcus aureus strains with decreased susceptibility to vancomycin.达托霉素对万古霉素敏感性降低的金黄色葡萄球菌菌株的杀菌活性以及纸片法和肉汤微量稀释法结果之间的相关性。
Antimicrob Agents Chemother. 2006 Jul;50(7):2330-6. doi: 10.1128/AAC.01491-05.
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Induction of daptomycin heterogeneous susceptibility in Staphylococcus aureus by exposure to vancomycin.通过暴露于万古霉素诱导金黄色葡萄球菌对达托霉素产生异质性药敏
Antimicrob Agents Chemother. 2006 Apr;50(4):1581-5. doi: 10.1128/AAC.50.4.1581-1585.2006.
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Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus.万古霉素中度敏感金黄色葡萄球菌中达托霉素敏感性降低与万古霉素耐药性之间的相关性
Antimicrob Agents Chemother. 2006 Mar;50(3):1079-82. doi: 10.1128/AAC.50.3.1079-1082.2006.
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Daptomycin: a novel agent for Gram-positive infections.达托霉素：一种用于革兰氏阳性菌感染的新型药物。
Expert Opin Investig Drugs. 1999 Aug;8(8):1223-38. doi: 10.1517/13543784.8.8.1223.
5
The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: mortality, length of stay, and hospital charges.金黄色葡萄球菌菌血症中耐甲氧西林对患者预后的影响：死亡率、住院时间和住院费用。
Infect Control Hosp Epidemiol. 2005 Feb;26(2):166-74. doi: 10.1086/502522.
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National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004.国家医院感染监测（NNIS）系统报告，1992年1月至2004年6月数据总结，2004年10月发布。
Am J Infect Control. 2004 Dec;32(8):470-85. doi: 10.1016/S0196655304005425.
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Vancomycin susceptibility within methicillin-resistant Staphylococcus aureus lineages.耐甲氧西林金黄色葡萄球菌谱系中的万古霉素敏感性
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Daptomycin: another novel agent for treating infections due to drug-resistant gram-positive pathogens.达托霉素：另一种用于治疗耐药革兰氏阳性病原体所致感染的新型药物。
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Antimicrobial resistance: the example of Staphylococcus aureus.抗菌药物耐药性：以金黄色葡萄球菌为例。
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10
The prevalence and mechanisms of vancomycin resistance in Staphylococcus aureus.金黄色葡萄球菌中万古霉素耐药性的流行情况及机制
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达托霉素和万古霉素对糖肽类中介金黄色葡萄球菌（GISA）及异质性GISA分离株的杀菌活性比较

Comparative bactericidal activities of daptomycin and vancomycin against glycopeptide-intermediate Staphylococcus aureus (GISA) and heterogeneous GISA isolates.

作者信息

Wootton Mandy, MacGowan Alasdair P, Walsh Timothy R

机构信息

Bristol Centre for Antimicrobial Research and Evaluation, Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, United Kingdom.

出版信息

Antimicrob Agents Chemother. 2006 Dec;50(12):4195-7. doi: 10.1128/AAC.00678-06. Epub 2006 Oct 16.

DOI:10.1128/AAC.00678-06
PMID:17043121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1693982/
Abstract

Staphylococcus aureus strains from the U.S. SENTRY Antimicrobial Surveillance Program, 2002-2003, glycopeptide-intermediate S. aureus (GISA) strains, and heterogeneous GISA (hGISA) strains were used to compare bactericidal activities of daptomycin and vancomycin using MICs and minimum bactericidal concentrations. Glycopeptide-susceptible S. aureus and hGISA strains were further studied by using time-kill curves. For all isolates, the daptomycin MIC50 and MIC90 are four times lower and the log drops in viable counts at 6 h and 24 h are significantly greater than those for vancomycin.

摘要

来自美国哨兵抗菌监测计划（2002 - 2003年）的金黄色葡萄球菌菌株、糖肽中介金黄色葡萄球菌（GISA）菌株以及异质性GISA（hGISA）菌株，被用于通过最低抑菌浓度（MIC）和最低杀菌浓度比较达托霉素和万古霉素的杀菌活性。对糖肽敏感的金黄色葡萄球菌和hGISA菌株通过时间杀菌曲线作进一步研究。对于所有分离株，达托霉素的MIC50和MIC90低四倍，且在6小时和24小时时活菌计数的对数下降显著大于万古霉素。