Khin Y T, Peh W C G, Lee V K M, Teo H E L, Ng S B, Nathan S S
Department of Diagnostic Radiology, KK Women's and Children's Hospital, Singapore.
Singapore Med J. 2009 Jan;50(1):e1-4.
A nine-year-old boy presented with increasingly worsening right shoulder pain of 18 months' duration. On physical examination, there was a tender firm swelling over the right upper arm. Radiographs showed a large osteolytic lesion in the proximal humeral diaphysis, with prominent mixed acute-on-chronic periosteal reaction in a lamellar fashion. There was a pathological fracture. The lesion appeared to be radiographically aggressive in nature. Bone scintiscan showed solitary marked uptake. On-table frozen section histopathological examination of the lesion showed an osteoblastic lesion with aggressive features. Completion curettage and high speed burring of the cavity was performed. In view of the patient's young age, which required a biological solution, and potential for local recurrence, that necessitated a radiopaque filler, the lesion was packed with a calcium phosphate cement paste. The final diagnosis was osteoblastoma with aggressive features. The patient remained well on follow-up to date. The filler continues to be remodelled to native tissue and there is no evidence of local recurrence. Osteoblastoma is a relatively rare benign tumour that typically occurs in the posterior elements of the vertebral column. The humerus is a very rare site of disease in the appendicular skeleton, and poses a diagnostic dilemma which implicates the possibility of osteogenic sarcoma.
一名9岁男孩出现右肩疼痛,持续18个月且逐渐加重。体格检查发现右上臂有压痛性坚实肿块。X线片显示肱骨近端骨干有一个大的溶骨性病变,伴有明显的混合性急性-慢性骨膜反应,呈板层状。存在病理性骨折。该病变在影像学上表现为侵袭性。骨扫描显示有孤立性明显摄取。术中对病变进行冰冻切片组织病理学检查,显示为具有侵袭性特征的成骨细胞性病变。对病变进行了彻底刮除并对骨腔进行高速磨钻处理。鉴于患者年龄小,需要生物解决方案,且有局部复发的可能,需要不透射线的填充物,遂用磷酸钙骨水泥糊剂填充病变。最终诊断为具有侵袭性特征的骨母细胞瘤。患者随访至今情况良好。填充物持续重塑为天然组织,无局部复发迹象。骨母细胞瘤是一种相对罕见的良性肿瘤,通常发生在脊柱的后部结构。在四肢骨骼中,肱骨是非常罕见的发病部位,会带来诊断难题,提示骨肉瘤的可能性。