Elizur Shai E, Tulandi Togas, Meterissian Sarkis, Huang Jack Y J, Levin Dan, Tan Seang Lin
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, McGill University, Montreal, Quebec H3A 1A1, Canada.
J Gastrointest Surg. 2009 Jun;13(6):1111-5. doi: 10.1007/s11605-009-0829-3. Epub 2009 Feb 18.
Up to 6% of women with colorectal cancer are diagnosed in the reproductive age and are at risk for premature ovarian failure and infertility due to pelvic irradiation and chemotherapy.
Between 1997 and 2007, six women with rectal carcinoma were referred to the McGill Reproductive Center (Montreal, Canada) for fertility preservation. Following resection of their primary tumor, they were scheduled to undergo pelvic irradiation.
Five patients underwent laparoscopic ovarian lateral transposition before radiotherapy in order to relocate their ovaries outside the radiation field. A concomitant ovarian wedge resection was performed for ovarian cryopreservation. In two of these women, before dissecting the ovarian cortical tissue for cryopreservation, all visible follicles were aspirated. The sixth patient who had had low anterior resection underwent hormonal ovarian stimulation followed by oocyte retrieval and embryo vitrification.
Fertility preservation in women with rectal cancer is feasible. This includes laparoscopic ovarian transposition and cryopreservation of ovarian tissue, embryo, or oocyte.
高达6%的结直肠癌女性患者在育龄期被诊断出患病，由于盆腔放疗和化疗，她们有过早出现卵巢功能衰竭和不孕的风险。
1997年至2007年期间，六名直肠癌女性患者被转诊至麦吉尔生殖中心（加拿大蒙特利尔）以保留生育能力。在切除原发肿瘤后，她们计划接受盆腔放疗。
五名患者在放疗前接受了腹腔镜下卵巢侧方移位术，以便将卵巢重新安置在辐射野之外。同时进行了卵巢楔形切除术以进行卵巢冷冻保存。在其中两名女性患者中，在解剖卵巢皮质组织进行冷冻保存之前，抽吸了所有可见卵泡。第六名接受低位前切除术的患者接受了激素卵巢刺激，随后进行了卵母细胞采集和胚胎玻璃化冷冻。
直肠癌女性患者保留生育能力是可行的。这包括腹腔镜下卵巢移位术以及卵巢组织、胚胎或卵母细胞的冷冻保存。
