Du Peng, O'Grady G, Egbuji J U, Lammers W J, Budgett D, Nielsen P, Windsor J A, Pullan A J, Cheng L K
Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Ann Biomed Eng. 2009 Apr;37(4):839-46. doi: 10.1007/s10439-009-9654-9. Epub 2009 Feb 18.
High-resolution, multi-electrode mapping is providing valuable new insights into the origin, propagation, and abnormalities of gastrointestinal (GI) slow wave activity. Construction of high-resolution mapping arrays has previously been a costly and time-consuming endeavor, and existing arrays are not well suited for human research as they cannot be reliably and repeatedly sterilized. The design and fabrication of a new flexible printed circuit board (PCB) multi-electrode array that is suitable for GI mapping is presented, together with its in vivo validation in a porcine model. A modified methodology for characterizing slow waves and forming spatiotemporal activation maps showing slow waves propagation is also demonstrated. The validation study found that flexible PCB electrode arrays are able to reliably record gastric slow wave activity with signal quality near that achieved by traditional epoxy resin-embedded silver electrode arrays. Flexible PCB electrode arrays provide a clinically viable alternative to previously published devices for the high-resolution mapping of GI slow wave activity. PCBs may be mass-produced at low cost, and are easily sterilized and potentially disposable, making them ideally suited to intra-operative human use.
高分辨率多电极标测为深入了解胃肠道（GI）慢波活动的起源、传播及异常情况提供了有价值的新见解。此前，构建高分辨率标测阵列成本高昂且耗时，现有的阵列不太适合人体研究，因为它们无法可靠且反复地进行消毒。本文介绍了一种适用于胃肠道标测的新型柔性印刷电路板（PCB）多电极阵列的设计与制造，并展示了其在猪模型中的体内验证。还演示了一种用于表征慢波并形成显示慢波传播的时空激活图的改进方法。验证研究发现，柔性PCB电极阵列能够可靠地记录胃慢波活动，其信号质量与传统环氧树脂嵌入银电极阵列相近。柔性PCB电极阵列可为先前发表的用于胃肠道慢波活动高分辨率标测的设备提供一种临床上可行的替代方案。PCB可以低成本大规模生产，易于消毒且可能一次性使用，使其非常适合在人体手术中使用。
