Menicanin Danijela, Bartold P Mark, Zannettino Andrew C W, Gronthos Stan
Mesenchymal Stem Cell Group, Bone and Cancer Laboratories, Division of Haematology, Institute of Medical and Veterinary Science/ Hanson Institute and CSCR, University of Adelaide, SA, Australia.
Stem Cell Rev Rep. 2009 Mar;5(1):36-50. doi: 10.1007/s12015-009-9056-2. Epub 2009 Feb 18.
Mesenchymal stem/stromal cells (MSC) are an accessible source of precursor cells that can be expanded in vitro and used for tissue regeneration for different clinical applications. The advent of microarray technology has enabled the monitoring of individual and global gene expression patterns across multiple cell populations. Thus, genomic profiling has fundamentally changed our capacity to characterize MSCs, identify potential biomarkers and determined key molecules regulating biological processes involved in stem cell survival, growth and development. Numerous studies have now examined the genomic profiles of MSCs derived from different tissues that exhibit varying levels of differentiation and proliferation potentials. The knowledge gained from these studies will help improve our understanding of the cellular signalling pathways involved in MSC growth, survival and differentiation, and may aid in the development of strategies to improve the tissue regeneration potential of MSCs for different clinical indications. The present review summarizes studies characterizing the gene expression profile of MSCs.
间充质干/基质细胞（MSC）是一种易于获取的前体细胞来源，可在体外扩增并用于不同临床应用的组织再生。微阵列技术的出现使得对多个细胞群体的个体和整体基因表达模式进行监测成为可能。因此，基因组分析从根本上改变了我们表征MSC、识别潜在生物标志物以及确定调节干细胞存活、生长和发育所涉及生物过程的关键分子的能力。现在，许多研究已经检测了来自不同组织的MSC的基因组图谱，这些MSC表现出不同程度的分化和增殖潜能。从这些研究中获得的知识将有助于我们更好地理解参与MSC生长、存活和分化的细胞信号通路，并可能有助于制定策略，以提高MSC在不同临床适应症中的组织再生潜能。本综述总结了表征MSC基因表达谱的研究。
