Simon Richard
National Cancer Institute, 9000 Rockville Pike, MSC 7434, Bethesda, MD 20892, United States.
Curr Opin Biotechnol. 2008 Feb;19(1):26-9. doi: 10.1016/j.copbio.2007.10.008. Epub 2007 Nov 28.
Microarray-based expression profiling is a powerful technology for studying biological mechanisms and for developing clinically valuable predictive classifiers. The high-dimensional read-out for each sample assayed makes it possible to do new kinds of studies but also increases the risks of misleading conclusions. We review here the current state-of-the-art for design and analysis of microarray-based investigations.
基于微阵列的表达谱分析是一种用于研究生物学机制和开发具有临床价值的预测分类器的强大技术。对每个检测样本的高维读出使得开展新型研究成为可能,但同时也增加了得出误导性结论的风险。我们在此回顾基于微阵列研究的设计与分析的当前技术水平。