Jim Heather S L, Donovan Kristine A, Small Brent J, Andrykowski Michael A, Munster Pamela N, Jacobsen Paul B
Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.
Cancer. 2009 Apr 15;115(8):1776-83. doi: 10.1002/cncr.24192.
The current study was performed to determine whether neuropsychologic functioning differs in breast cancer survivors 6 months after the completion of adjuvant treatment compared with women without cancer.
Participants were 187 women who were diagnosed with ductal carcinoma in situ or stage I or stage II breast cancer and 187 age-matched and geographically matched women without cancer. Of the survivors, 97 had been treated after surgery with chemotherapy only or chemotherapy plus radiotherapy and 90 had been treated after surgery with radiotherapy only (grading determined according to the American Joint Committee on Cancer grading system).
Small but statistically significant differences in cognitive functioning and cognitive impairment were observed in those survivors who were treated with chemotherapy and their matched controls, as well as in survivors treated with radiotherapy only and their matched controls. No group differences were observed with regard to cognitive symptoms.
Data from the current study suggest that cognitive deficits are subtle and likely the result of the general effects of cancer diagnosis and treatment rather than systemic treatment.
本研究旨在确定辅助治疗结束6个月后的乳腺癌幸存者与未患癌症的女性相比，其神经心理功能是否存在差异。
参与者为187名被诊断为原位导管癌或I期或II期乳腺癌的女性以及187名年龄匹配且地理位置匹配的未患癌症的女性。在幸存者中，97名在手术后仅接受了化疗或化疗加放疗，90名在手术后仅接受了放疗（分级根据美国癌症联合委员会分级系统确定）。
在接受化疗的幸存者及其匹配对照中，以及在仅接受放疗的幸存者及其匹配对照中，观察到认知功能和认知障碍存在微小但具有统计学意义的差异。在认知症状方面未观察到组间差异。
本研究数据表明，认知缺陷很细微，可能是癌症诊断和治疗的总体影响而非全身治疗的结果。
