使用在室温下保存长达六年的干血斑测定1型人类免疫缺陷病毒阳性婴儿中的奈韦拉平耐药性。
Nevirapine resistance in human immunodeficiency virus type 1-positive infants determined using dried blood spots stored for up to six years at room temperature.
作者信息
Nelson Julie A E, Loftis Amy M, Kamwendo Deborah, Fawzi Wafaie W, Taha Taha E, Goldenberg Robert L, Fiscus Susan A
机构信息
Department of Microbiology and Immunology, UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
出版信息
J Clin Microbiol. 2009 Apr;47(4):1209-11. doi: 10.1128/JCM.00254-09. Epub 2009 Feb 18.
Abstract
Dried blood spots that had been stored ambiently for 3 to 6 years lost approximately 1 log(10) of human immunodeficiency virus type 1 (HIV-1) RNA, but the majority could still be genotyped for resistance. Nevirapine resistance was found in 7/16 (43.5%) HIV-1-positive HIVNET 024 infants at 4 to 6 weeks, but no resistance was found at other time points.
摘要
在室温下储存3至6年的干血斑，其1型人类免疫缺陷病毒（HIV-1）RNA大约损失1个对数（10），但大多数仍可进行耐药性基因分型。在4至6周龄时，16例HIV-1阳性的HIVNET 024婴儿中有7例（43.5%）发现奈韦拉平耐药，但在其他时间点未发现耐药情况。
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