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Qualitative human immunodeficiency virus RNA analysis of dried blood spots for diagnosis of infections in infants.用于诊断婴儿感染的干血斑的定性人类免疫缺陷病毒RNA分析。
J Clin Microbiol. 2009 Jan;47(1):220-2. doi: 10.1128/JCM.01521-08. Epub 2008 Nov 12.
2
Detection of low levels of human immunodeficiency virus (HIV) may be critical for early diagnosis of pediatric HIV infection by use of dried blood spots.检测低水平的人类免疫缺陷病毒（HIV）对于通过干血斑早期诊断儿童HIV感染可能至关重要。
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Diagnosis of human immunodeficiency virus type 1 infection in infants by use of dried blood spots and an ultrasensitive p24 antigen assay.利用干血斑和超灵敏p24抗原检测法诊断婴儿1型人类免疫缺陷病毒感染
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A novel RealTime HIV-1 Qualitative assay for the detection of HIV-1 nucleic acids in dried blood spots and plasma.一种新型实时 HIV-1 定性检测法，用于检测干血斑和血浆中的 HIV-1 核酸。
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Performance of a novel human immunodeficiency virus (HIV) type 1 total nucleic acid-based real-time PCR assay using whole blood and dried blood spots for diagnosis of HIV in infants.一种基于新型1型人类免疫缺陷病毒（HIV）全核酸的实时聚合酶链反应检测方法在使用全血和干血斑诊断婴儿HIV中的性能。
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Ultra-high-throughput, automated nucleic acid detection of human immunodeficiency virus (HIV) for infant infection diagnosis using the Gen-Probe Aptima HIV-1 screening assay.使用Gen-Probe Aptima HIV-1筛查检测法对人类免疫缺陷病毒（HIV）进行超高通量自动化核酸检测，用于婴儿感染诊断。
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Evaluation of different RNA extraction methods and storage conditions of dried plasma or blood spots for human immunodeficiency virus type 1 RNA quantification and PCR amplification for drug resistance testing.评估用于1型人类免疫缺陷病毒RNA定量及耐药性检测的PCR扩增的不同RNA提取方法以及干血浆或血斑的储存条件。
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Nevirapine resistance in human immunodeficiency virus type 1-positive infants determined using dried blood spots stored for up to six years at room temperature.使用在室温下保存长达六年的干血斑测定1型人类免疫缺陷病毒阳性婴儿中的奈韦拉平耐药性。
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Comparison of the Gen-Probe Aptima HIV-1 and Abbott HIV-1 qualitative assays with the Roche Amplicor HIV-1 DNA assay for early infant diagnosis using dried blood spots.使用干血斑对Gen-Probe Aptima HIV-1和雅培HIV-1定性检测法与罗氏Amplicor HIV-1 DNA检测法进行早期婴儿诊断的比较。
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Early diagnosis of human immunodeficiency virus-1 infection in infants with the NucliSens EasyQ assay on dried blood spots.应用干血斑 NucliSens EasyQ 检测试剂快速诊断婴儿人类免疫缺陷病毒-1 感染。
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Comparison of the Gen-Probe Aptima HIV-1 and Abbott HIV-1 qualitative assays with the Roche Amplicor HIV-1 DNA assay for early infant diagnosis using dried blood spots.使用干血斑对Gen-Probe Aptima HIV-1和雅培HIV-1定性检测法与罗氏Amplicor HIV-1 DNA检测法进行早期婴儿诊断的比较。
J Clin Virol. 2014 Aug;60(4):418-21. doi: 10.1016/j.jcv.2014.05.012. Epub 2014 Jun 2.
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Early diagnosis of in utero and intrapartum HIV infection in infants prior to 6 weeks of age.在婴儿出生后 6 周之前，对宫内和产时 HIV 感染进行早期诊断。
J Clin Microbiol. 2012 Jul;50(7):2373-7. doi: 10.1128/JCM.00431-12. Epub 2012 Apr 18.
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Evaluation of the Gen-Probe Aptima HIV-1 RNA qualitative assay as an alternative to Western blot analysis for confirmation of HIV infection.评价 Gen-Probe Aptima HIV-1 RNA 定性检测作为替代 Western blot 分析用于确认 HIV 感染的方法。
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本文引用的文献

1
Screening and confirmation of human immunodeficiency virus type 1 infection solely by detection of RNA.仅通过检测RNA对1型人类免疫缺陷病毒感染进行筛查和确认。
J Med Microbiol. 2008 Oct;57(Pt 10):1228-1233. doi: 10.1099/jmm.0.2008/002386-0.
2
Highly sensitive methods based on seminested real-time reverse transcription-PCR for quantitation of human immunodeficiency virus type 1 unspliced and multiply spliced RNA and proviral DNA.基于半巢式实时逆转录聚合酶链反应的高灵敏度方法，用于定量人类免疫缺陷病毒1型未剪接和多次剪接的RNA以及前病毒DNA。
J Clin Microbiol. 2008 Jul;46(7):2206-11. doi: 10.1128/JCM.00055-08. Epub 2008 May 7.
3
Early diagnosis of human immunodeficiency virus in infants using polymerase chain reaction on dried blood spots in Botswana's national program for prevention of mother-to-child transmission.在博茨瓦纳预防母婴传播国家项目中，利用干血斑上的聚合酶链反应对婴儿进行人类免疫缺陷病毒早期诊断。
Pediatr Infect Dis J. 2008 Jan;27(1):22-6. doi: 10.1097/INF.0b013e3181469050.
4
Early infant human immunodeficiency virus type 1 detection suitable for resource-limited settings with multiple circulating subtypes by use of nested three-monoplex DNA PCR and dried blood spots.通过使用巢式三重单重DNA聚合酶链反应和干血斑，在资源有限且存在多种流行亚型的环境中进行早期婴儿1型人类免疫缺陷病毒检测。
J Clin Microbiol. 2008 Feb;46(2):721-6. doi: 10.1128/JCM.01539-07. Epub 2007 Dec 12.
5
Evaluation of the ultrasensitive human immunodeficiency virus type 1 (HIV-1) p24 antigen assay performed on dried blood spots for diagnosis of HIV-1 infection in infants.对用于诊断婴儿1型人类免疫缺陷病毒（HIV-1）感染的干血斑超敏HIV-1 p24抗原检测法的评估。
Clin Vaccine Immunol. 2008 Feb;15(2):388-91. doi: 10.1128/CVI.00265-07. Epub 2007 Dec 5.
6
Identification of HIV-1 infected infants and young children using real-time RT PCR and dried blood spots from Uganda and Cameroon.利用实时逆转录聚合酶链反应和来自乌干达及喀麦隆的干血斑鉴定HIV-1感染的婴幼儿。
J Virol Methods. 2007 Sep;144(1-2):109-14. doi: 10.1016/j.jviromet.2007.04.003. Epub 2007 Jun 5.
7
Evaluation of dried whole blood spots obtained by heel or finger stick as an alternative to venous blood for diagnosis of human immunodeficiency virus type 1 infection in vertically exposed infants in the routine diagnostic laboratory.在常规诊断实验室中，评估足跟或手指采血获得的干血斑作为静脉血的替代样本，用于诊断垂直暴露婴儿的1型人类免疫缺陷病毒感染。
Clin Vaccine Immunol. 2007 Feb;14(2):201-3. doi: 10.1128/CVI.00223-06. Epub 2006 Dec 13.
8
The HPTN 024 Study: the efficacy of antibiotics to prevent chorioamnionitis and preterm birth.HPTN 024研究：抗生素预防绒毛膜羊膜炎和早产的疗效。
Am J Obstet Gynecol. 2006 Mar;194(3):650-61. doi: 10.1016/j.ajog.2006.01.004.
9
Ultrasensitive human immunodeficiency virus type 1 p24 antigen assay modified for use on dried whole-blood spots as a reliable, affordable test for infant diagnosis.超灵敏1型人类免疫缺陷病毒p24抗原检测法经改良后可用于干血斑检测，作为一种可靠且经济实惠的婴儿诊断检测方法。
Clin Vaccine Immunol. 2006 Jan;13(1):152-5. doi: 10.1128/CVI.13.1.152-155.2006.
10
Multicenter evaluation of use of dried blood and plasma spot specimens in quantitative assays for human immunodeficiency virus RNA: measurement, precision, and RNA stability.多中心评估干血斑和血浆斑标本在人类免疫缺陷病毒RNA定量检测中的应用：测量、精密度和RNA稳定性
J Clin Microbiol. 2003 May;41(5):1888-93. doi: 10.1128/JCM.41.5.1888-1893.2003.

用于诊断婴儿感染的干血斑的定性人类免疫缺陷病毒RNA分析。

Qualitative human immunodeficiency virus RNA analysis of dried blood spots for diagnosis of infections in infants.

作者信息

Kerr Ryan J S, Player Gray, Fiscus Susan A, Nelson Julie A E

机构信息

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 11-141 Lineberger Cancer Center, CB 7295, Chapel Hill, NC 27599, USA.

出版信息

J Clin Microbiol. 2009 Jan;47(1):220-2. doi: 10.1128/JCM.01521-08. Epub 2008 Nov 12.

DOI:10.1128/JCM.01521-08
PMID:19005148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2620881/
Abstract

The Gen-Probe Aptima human immunodeficiency virus type 1 (HIV-1) RNA assay was adapted for the diagnosis of HIV infection in infants by using dried blood spots. The assay was 99% sensitive (128/129) and 100% specific (162/162). This may prove useful in resource-limited settings, since it precludes the need for a phlebotomist and maintenance of a cold chain.

摘要

Gen-Probe Aptima 1型人类免疫缺陷病毒（HIV-1）RNA检测方法经调整后，可用于通过干血斑诊断婴儿的HIV感染。该检测方法的灵敏度为99%（128/129），特异性为100%（162/162）。这在资源有限的环境中可能会很有用，因为它无需采血技师，也无需冷链维护。