Roberts Timothy V, Hodge Chris, Graham Stuart L, Burlutsky George, Mitchell Paul
Department of Ophthalmology, Royal North Shore Hospital, Australia.
J Glaucoma. 2009 Feb;18(2):114-8. doi: 10.1097/IJG.0b013e318179f80c.
To evaluate the prevalence of nocturnal oxygen desaturation and sleep-disordered breathing symptoms within a glaucoma population.
One hundred and twelve subjects (glaucoma=52, control=60) aged between 45 and 80 years were recruited for the study. Clinical assessment included overnight ambulatory pulse oximetry monitoring and administration of a self-reported sleep-disordered breathing questionnaire.
There were no differences in age, sex, body mass index, or prevalence of systemic hypertension between the groups. The mean oxygen desaturation index of the glaucoma group (8.6) did not differ significantly from that of the control group (9.6) (P=0.715). The prevalence of moderate to severe respiratory dysfunction (oxygen desaturation index >20) in the glaucoma group (17%) was similar to that in the control group (12%) (P=0.463). The severity of sleep-disordered breathing symptoms was similar between the groups (P=0.157).
No statistically significant association was found between glaucoma and either nocturnal oxygen desaturation or sleep-disordered breathing. Although this study cannot exclude the possibility of either impaired optic nerve head autoregulation or hypoxic damage occurring secondary to sleep apnea syndrome, the findings do not support the routine use of pulse oximetry in the workup of individuals with glaucoma.
评估青光眼患者夜间氧饱和度降低和睡眠呼吸紊乱症状的发生率。
招募了112名年龄在45至80岁之间的受试者（青光眼患者52名，对照组60名）进行该研究。临床评估包括夜间动态脉搏血氧饱和度监测以及一份自我报告的睡眠呼吸紊乱问卷。
两组在年龄、性别、体重指数或系统性高血压患病率方面无差异。青光眼组的平均氧饱和度降低指数（8.6）与对照组（9.6）相比无显著差异（P = 0.715）。青光眼组中重度呼吸功能障碍（氧饱和度降低指数>20）的发生率（17%）与对照组（12%）相似（P = 0.463）。两组睡眠呼吸紊乱症状的严重程度相似（P = 0.157）。
未发现青光眼与夜间氧饱和度降低或睡眠呼吸紊乱之间存在统计学上的显著关联。尽管本研究不能排除视神经乳头自动调节受损或睡眠呼吸暂停综合征继发缺氧损伤的可能性，但研究结果不支持在青光眼患者的检查中常规使用脉搏血氧饱和度测定法。
