Sawaya Heloisa Helena Braga, de Souza Romy Beatriz Christmann, Carrasco Solange, Goldenstein-Schainberg Claudia
Massachusetts General Hospital, Harvard University, Cambridge, USA.
Clin Rheumatol. 2009 Jul;28(7):847-51. doi: 10.1007/s10067-009-1124-0. Epub 2009 Feb 19.
The aim of the study was to evaluate the expressions of adhesion molecules (AM) on peripheral blood mononuclear cells (PBMNC) from systemic sclerosis (SSc) patients. Thirty-one SSc patients (ACR) and 20 normal subjects were selected for the study. PBMNC were analyzed for LFA-1alpha, LFA-1beta, ICAM-3, ICAM-1, and L: -selectin expressions. ICAM-3 expression was decreased while ICAM-1 was increased on SSc PBMNC, compared to controls (p = 0.04 and 0.003, respectively). A positive association was found between LFA-1alpha (r = 0.37, p = 0.03), LFA-1beta (r = 0.38, p = 0.002), ICAM-3 (r = 0.42, p = 0.01), and L-selectin (r = 0.38, p = 0.03) expressions and greater number of immunosuppressive drugs taken by SSc patients. Also, anti-centromeric positive SSc patients had lower expressions of LFA-1alpha, LFA-1beta, ICAM-3, and L-selectin. Lower expression of ICAM-3 and higher expression of ICAM-1 suggest that AMs may be involved in the pathogenesis of scleroderma.
该研究的目的是评估系统性硬化症（SSc）患者外周血单个核细胞（PBMNC）上黏附分子（AM）的表达。选取31例（美国风湿病学会标准）SSc患者和20名正常受试者进行研究。分析PBMNC的淋巴细胞功能相关抗原-1α（LFA-1α）、淋巴细胞功能相关抗原-1β（LFA-1β）、细胞间黏附分子-3（ICAM-3）、细胞间黏附分子-1（ICAM-1）和L-选择素的表达。与对照组相比，SSc患者的PBMNC上ICAM-3表达降低而ICAM-1表达增加（p值分别为0.04和0.003）。发现SSc患者的LFA-1α（r = 0.37，p = 0.03）、LFA-1β（r = 0.38，p = 0.002）、ICAM-3（r = 0.42，p = 0.01）和L-选择素（r = 0.38，p = 0.03）表达与服用更多种类的免疫抑制药物之间呈正相关。此外，抗着丝点抗体阳性的SSc患者LFA-1α、LFA-1β、ICAM-3和L-选择素的表达较低。ICAM-3的低表达和ICAM-1的高表达表明黏附分子可能参与了硬皮病的发病机制。
