Lempert Thomas, Neuhauser Hannelore
Dept. of Neurology, Schlosspark-Klinik, Heubnerweg 2, 14059, Berlin, Germany.
J Neurol. 2009 Mar;256(3):333-8. doi: 10.1007/s00415-009-0149-2. Epub 2009 Feb 17.
Both migraine and vertigo are common in the general population with lifetime prevalences of about 16 % for migraine and 7 % for vertigo. Therefore, a concurrence of the two conditions can be expected in about 1.1 % of the general population by chance alone. However, recent epidemiological evidence suggests that the actual comorbidity is higher, namely 3.2 %. This can be explained by the fact that several dizziness and vertigo syndromes occur more frequently in migraineurs than in controls including benign paroxysmal positional vertigo, Meniere's disease, motion sickness, cerebellar disorders and anxiety syndromes which may present with dizziness. In addition, there is increasing recognition of a syndrome called vestibular migraine (VM), which is vertigo directly caused by migraine. VM affects more than 1 % of the general population, about 10 % of patients in dizziness clinics and at least 9 % of patients in migraine clinics.Clinically, VM presents with attacks of spontaneous or positional vertigo lasting seconds to days. Migrainous accompaniments such as headache, phonophobia, photophobia or auras are common but not mandatory. Cochlear symptoms may be associated but are mostly mild and non-progressive. During acute attacks one may find central spontaneous or positional nystagmus and, less commonly, unilateral vestibular hypofunction. In the symptom-free interval, vestibular testing adds little to the diagnosis as findings are mostly minor and non-specific. In the absence of controlled studies, treatment of VM is adopted from the migraine sphere comprising avoidance of triggers, stress management as well as pharmacotherapy for acute attacks and prophylaxis.
偏头痛和眩晕在普通人群中都很常见,偏头痛的终生患病率约为16%,眩晕的终生患病率约为7%。因此,仅随机因素就可预期这两种情况在约1.1%的普通人群中同时出现。然而,最近的流行病学证据表明,实际的合并症发生率更高,即3.2%。这可以用以下事实来解释:几种头晕和眩晕综合征在偏头痛患者中比在对照组中更频繁出现,包括良性阵发性位置性眩晕、梅尼埃病、晕动病、小脑疾病以及可能表现为头晕的焦虑综合征。此外,人们越来越认识到一种称为前庭性偏头痛(VM)的综合征,它是由偏头痛直接引起的眩晕。VM影响超过1%的普通人群,在头晕诊所约占患者的10%,在偏头痛诊所至少占患者的9%。临床上,VM表现为持续数秒至数天的自发性或位置性眩晕发作。偏头痛伴随症状如头痛、畏声、畏光或先兆很常见,但并非必需。耳蜗症状可能会出现,但大多较轻且无进展。在急性发作期间,可能会发现中枢性自发性或位置性眼球震颤,较少见的是单侧前庭功能减退。在无症状期,前庭测试对诊断帮助不大,因为检查结果大多轻微且不具特异性。在缺乏对照研究的情况下,VM的治疗采用偏头痛领域的方法,包括避免触发因素、压力管理以及急性发作和预防的药物治疗。