Nicolosi A, Hauser W A, Musicco M, Kurland L T
Department of Epidemiology, Institute of Advanced Biomedical Technologies, National Research Council, Milan, Italy.
Neuroepidemiology. 1991;10(3):122-31. doi: 10.1159/000110257.
The incidence of brain abscess was studied on all cases occurring in residents of Olmsted County, Minn., from 1935 through 1981. Thirty-eight cases (9 cases first diagnosed at autopsy) were identified and followed through the Rochester Olmsted County medical record-linkage system at the Mayo Clinic. The incidence rate was 1.3/100,000 person-years (PY), 1.9 in males and 0.6 in females. Incidence decreased from 2.7 in 1935-44 to 0.9 in 1965-81. Rates were higher in children 5-9 years old (2.4) and after age 60 (2.6 PY). An etiologic agent was identified in 29 cases (76%) with streptococci being the most frequently isolated. Case-fatality ratio was 38% (11/29), stable over time. Concurrent bacterial meningitis was the strongest predictor of death. Neurologic sequelae were observed in 8 (44%) of the 18 surviving patients including epilepsy (5 cases), deafness and motor impairment.
对1935年至1981年间明尼苏达州奥尔姆斯特德县居民中发生的所有脑脓肿病例进行了发病率研究。共识别出38例（9例首次在尸检时确诊），并通过梅奥诊所的罗切斯特奥尔姆斯特德县医疗记录关联系统进行随访。发病率为1.3/10万人口年（PY），男性为1.9，女性为0.6。发病率从1935 - 1944年的2.7降至1965 - 1981年的0.9。5 - 9岁儿童（2.4）和60岁以后（2.6 PY）的发病率较高。29例（76%）确定了病原体，其中链球菌最常分离出。病死率为38%（11/29），随时间稳定。并发细菌性脑膜炎是死亡的最强预测因素。18例存活患者中有8例（44%）出现神经后遗症，包括癫痫（5例）、耳聋和运动障碍。
