Manfè A Z, Grigoletto R, De Silvestro G, Bernante P, Faccioli A M
Istituto di Patologia Chirurgica II, Università di Padova.
Minerva Chir. 1991 May 31;46(10):511-5.
Immunodepression is a common condition in patients undergoing elective operations and it constitutes a high risk for the onset of postoperative infective complications. The use of immunomodulatory drugs has proved useful in the prophylaxis of these complications, although the precise indications for each drug have not yet been clearly codified. The present study aimed to assess the effects of thymostimulin in patients with different degrees of immunodepression, by evaluating both the incidence of postoperative infections and the changes induced in various immunological parameters. The results obtained indicated that those subjects with the highest degree of immunodepression (hypo-anergic) benefited most from drug therapy in comparison to those with a lesser degree of immunodepression (relatively hypo-ergic). The advantages were evident in hypo-anergic subjects both with regard to the frequency of early postoperative infections, and with regard to immunological parameters. On the other hand, in relatively hypo-ergic subjects, benefits were limited to the improvement of some immunological parameters. In our opinion, the use of thymostimulin is of particular use only in those subjects with marked immunodepression since the incidence of post-operative sepsis is highest in this group.
免疫抑制是择期手术患者的常见情况，它构成了术后感染性并发症发生的高风险因素。免疫调节药物的使用已被证明对预防这些并发症有用，尽管每种药物的确切适应证尚未明确编纂。本研究旨在通过评估术后感染的发生率以及各种免疫参数的变化，来评估胸腺刺激素对不同程度免疫抑制患者的影响。获得的结果表明，与免疫抑制程度较轻（相对低反应性）的患者相比，免疫抑制程度最高（低反应性）的患者从药物治疗中获益最大。这些优势在低反应性患者中，无论是早期术后感染的频率还是免疫参数方面都很明显。另一方面，在相对低反应性患者中，益处仅限于一些免疫参数的改善。我们认为，胸腺刺激素仅在那些有明显免疫抑制的患者中特别有用，因为该组术后败血症的发生率最高。
