PTIP对组蛋白甲基化和基因组稳定性的调控
Control of histone methylation and genome stability by PTIP.
作者信息
Muñoz Ivan M, Rouse John
机构信息
Medical Research Council Protein Phosphorylation Unit, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, UK.
出版信息
EMBO Rep. 2009 Mar;10(3):239-45. doi: 10.1038/embor.2009.21. Epub 2009 Feb 20.
Abstract
PTIP regulates gene transcription by controlling the methylation of histone H3, and also has important roles in cellular responses to DNA damage or to perturbed DNA replication. The available data suggest that the functions of PTIP in transcription and preserving genome stability might be independent and mediated by functionally distinct cellular pools of PTIP. Although considerable progress has been made in understanding how PTIP influences transcription, a coherent picture of how it protects cells from DNA damage at the molecular level has yet to emerge. Here, we describe recent progress made in understanding the cellular roles of PTIP and the relevance of PTIP-interacting proteins, as well as the questions that have yet to be answered.
摘要
PTIP 通过控制组蛋白 H3 的甲基化来调节基因转录，并且在细胞对 DNA 损伤或 DNA 复制紊乱的反应中也发挥重要作用。现有数据表明，PTIP 在转录和维持基因组稳定性方面的功能可能是独立的，且由功能不同的 PTIP 细胞池介导。尽管在理解 PTIP 如何影响转录方面已经取得了相当大的进展，但在分子水平上它如何保护细胞免受 DNA 损伤的连贯图景尚未形成。在这里，我们描述了在理解 PTIP 的细胞作用、PTIP 相互作用蛋白的相关性以及尚未解答的问题方面取得的最新进展。
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2
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3
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