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儿童恶性骨肿瘤中的可扩张内假体:适应证与局限性

Expandable endoprostheses in malignant bone tumors in children: indications and limitations.

作者信息

Baumgart Rainer, Lenze Ulrich

机构信息

Zentrum für korrigierende und rekonstruktive, Extremittätenchirurgie Miinchen (ZEM), Limb Lengthening Center Munich/Germany, Nymphenburgerstr. 1, 80335 Munich, Germany.

出版信息

Recent Results Cancer Res. 2009;179:59-73. doi: 10.1007/978-3-540-77960-5_6.

Abstract

Expandable endoprostheses can be an option after resection of malignant bone tumors of the lower extremity in children and adolescents not only to bridge the resultant surgical defect but also to correct a residual limb length discrepancy. Small intramedullary diameter and short residual bone segments, as well as stress-shielding, are intrinsic technical limitations of fully implantable reconstructive devices. As a consequence, until recently, repeated operative interventions to reconstruct the limb and compensate for subsequent absence of growth within the affected limb were required to compensate for continued growth of the contralateral limb. Innovative expandable endoprosthetic devices are now available to help achieve equal limb length at maturity. One common device is a conventional endoprosthesis that is lengthened using a telescopic module, whereas the "bioexpandable" system lengthens the remaining bone using a lengthening nail as a modular part of the endoprosthesis. Both systems are equipped with motor drives that electromagnetic waves activate transcutaneously. One advantage of the "bioexpandable" endoprosthesis is that with sequential lengthening, the proportion of residual bone shaft to prosthesis length increases, thereby diminishing host bone-endoprosthetic lever arm forces.

摘要

可扩张内假体可作为儿童和青少年下肢恶性骨肿瘤切除术后的一种选择,不仅用于填补由此产生的手术缺损,还用于纠正肢体长度残留差异。髓内直径小、残留骨段短以及应力遮挡是完全可植入重建装置固有的技术限制。因此,直到最近,仍需要反复进行手术干预来重建肢体并补偿患侧肢体随后生长的缺失,以补偿对侧肢体的持续生长。现在有创新的可扩张内假体装置可帮助在成熟时实现肢体等长。一种常见的装置是使用伸缩模块延长的传统内假体,而“生物可扩张”系统使用延长钉作为内假体的模块化部件来延长剩余骨骼。这两种系统都配备有由电磁波经皮激活的电机驱动器。“生物可扩张”内假体的一个优点是,随着顺序延长,残留骨干与假体长度的比例增加,从而减小宿主骨 - 内假体杠杆臂力。

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