Maggi F, Bendinelli M
Virology Unit, Pisa University Hospital, 35-37, Via San Zeno, I-56127 Pisa, Italy.
Curr Top Microbiol Immunol. 2009;331:65-90. doi: 10.1007/978-3-540-70972-5_5.
Many features of the Torque teno virus and the other anelloviruses (AVs) that have been identified after this virus was discovered in 1997 remain elusive. The immunobiology of the AVs is no exception. However, evidence is progressively accumulating that at least some AVs have an interesting interplay with cells and soluble factors known to contribute to the homeostasis of innate and adaptive immunity. Evidence is also accumulating that this interplay can have a significant impact on how effectively an infected host can deal with superimposed infectious and non-infectious noxae. This review article discusses the scanty information available on these aspects and highlights the ones that would be more urgent to precisely understand in order to get an adequate assessment of how important for human health these extremely ubiquitous and pervasive viruses really are.
自1997年发现Torque teno病毒（TTV）以来，已鉴定出的TTV和其他环病毒（AVs）的许多特征仍不明确。AVs的免疫生物学也不例外。然而，越来越多的证据表明，至少某些AVs与已知有助于先天免疫和适应性免疫稳态的细胞及可溶性因子存在有趣的相互作用。也有越来越多的证据表明，这种相互作用会对受感染宿主应对叠加的传染性和非传染性损伤的有效性产生重大影响。本文综述了这些方面的现有少量信息，并强调了为充分评估这些极其普遍存在的病毒对人类健康的真正重要性而更迫切需要精确了解的方面。
