泛音迁移谱法：第2部分。分辨能力的理论考量。
Overtone mobility spectrometry: part 2. Theoretical considerations of resolving power.
作者信息
Valentine Stephen J, Stokes Sarah T, Kurulugama Ruwan T, Nachtigall Fabiane M, Clemmer David E
机构信息
Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA.
出版信息
J Am Soc Mass Spectrom. 2009 May;20(5):738-50. doi: 10.1016/j.jasms.2009.01.001. Epub 2009 Jan 8.
Abstract
The transport of ions through multiple drift regions is modeled to develop an equation that is useful for an understanding of the resolving power of an overtone mobility spectrometry (OMS) technique. It is found that resolving power is influenced by a number of experimental variables, including those that define ion mobility spectrometry (IMS) resolving power: drift field (E), drift region length (L), and buffer gas temperature (T). However, unlike IMS, the resolving power of OMS is also influenced by the number of drift regions (n), harmonic frequency value (m), and the phase number (Phi) of the applied drift field. The OMS resolving power dependence upon the new OMS variables (n, m, and Phi) scales differently than the square root dependence of the E, L, and T variables in IMS. The results provide insight about optimal instrumental design and operation.
摘要
对离子通过多个漂移区的传输进行建模，以推导出一个有助于理解泛音迁移谱（OMS）技术分辨能力的方程。研究发现，分辨能力受许多实验变量的影响，包括那些定义离子迁移谱（IMS）分辨能力的变量：漂移场（E）、漂移区长度（L）和缓冲气体温度（T）。然而，与IMS不同的是，OMS的分辨能力还受漂移区数量（n）、谐波频率值（m）和所施加漂移场的相数（Phi）的影响。OMS分辨能力对新的OMS变量（n、m和Phi）的依赖性与IMS中E、L和T变量的平方根依赖性具有不同的比例关系。这些结果为最佳仪器设计和操作提供了见解。
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