Wheadon M, Goulding A, Barbezat G O, Campbell A J
Department of Medicine, University of Otago Medical School, Dunedin.
N Z Med J. 1991 Oct 9;104(921):417-9.
to evaluate the prevalence of lactose malabsorption and to assess dietary calcium intake, in elderly New Zealand women with hip fractures, in age matched case controls without hip fractures drawn from general practice, and in healthy young women.
lactose malabsorption was assessed by measuring breath hydrogen after a 50 g oral lactose tolerance test. Dietary calcium was estimated from a food frequency questionnaire.
the elderly fracture cases (n = 15), and their elderly controls (n = 16), showed a similar (60% and 63% respectively), but significantly higher prevalence (p less than 0.001), of lactose malabsorption than young women (12%, n = 50). Dietary calcium intake was similar in lactose absorbers and malabsorbers.
malabsorption of lactose occurs commonly in elderly New Zealand women but is scarce in young adults. A high prevalence of lactose malabsorption may be a risk factor for exacerbation of type II osteoporosis in the elderly.
评估新西兰老年髋部骨折女性、来自全科医疗的年龄匹配无髋部骨折的对照者以及健康年轻女性中乳糖吸收不良的患病率,并评估膳食钙摄入量。
通过口服50克乳糖耐量试验后测量呼气氢气来评估乳糖吸收不良。通过食物频率问卷估计膳食钙摄入量。
老年骨折病例(n = 15)及其老年对照者(n = 16)乳糖吸收不良的患病率相似(分别为60%和63%),但显著高于年轻女性(12%,n = 50)(p < 0.001)。乳糖吸收者和吸收不良者的膳食钙摄入量相似。
乳糖吸收不良在新西兰老年女性中普遍存在,但在年轻人中很少见。乳糖吸收不良的高患病率可能是老年女性II型骨质疏松症加重的一个危险因素。