Suga K, Honma Y, Uchisako H, Kuramitsu T, Tanaka N, Itou K, Ariyoshi I, Nakanishi T
Department of Radiology, Yamaguchi University School of Medicine, Japan.
Nucl Med Commun. 1991 Jul;12(7):611-9. doi: 10.1097/00006231-199107000-00005.
Tumour scintigraphy using 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HMPAO) was investigated in VX-2 tumours implanted in the muscles of the lower legs of rabbits to assess the feasibility of using this agent clinically for this procedure. On the time-activity curves for 99Tcm-HMPAO in the tumour, an initial peak and a subsequent decrease of radioactivity immediately after the initial peak were observed, while there was a slow, gradual decrease of activity over the next hour. The tumour/normal muscle ratio of HMPAO activity during this period was high and constant, and was independent of time. Comparison of the static images of 99Tcm-HMPAO with angiography and histological findings suggests that the tumour image of 99Tcm-HMPAO reflects tumour blood perfusion. These findings indicate that the distribution of 99Tcm-HMPAO on static images can provide a qualitative assessment of the perfusion of the tumour, despite the limitations of this tracer for quantifying tumour blood flow due to its early efflux from the tumour.
使用99锝-六甲基丙烯胺肟（99Tcm-HMPAO）进行肿瘤闪烁显像，在植入兔小腿肌肉的VX-2肿瘤中进行研究，以评估临床上使用该药物进行此操作的可行性。在肿瘤内99Tcm-HMPAO的时间-活性曲线上，观察到一个初始峰值以及初始峰值后放射性立即下降，而在接下来的一小时内活性缓慢逐渐下降。在此期间，HMPAO活性的肿瘤/正常肌肉比值高且恒定，并且与时间无关。99Tcm-HMPAO的静态图像与血管造影和组织学结果的比较表明，99Tcm-HMPAO的肿瘤图像反映了肿瘤的血液灌注。这些发现表明，尽管该示踪剂由于其早期从肿瘤中流出而在量化肿瘤血流方面存在局限性，但99Tcm-HMPAO在静态图像上的分布可以提供对肿瘤灌注的定性评估。
