De Feo Fabio, Roccatagliata Luca, Bonzano Laura, Castelletti Lara, Mancardi Gianluigi, Traverso Carlo Enrico
Centro di Ricerca Clinica e Laboratorio per il Glaucoma e la Cornea, Clinica Oculistica, Di.N.O.G., University of Genova, Genova, Italy.
Am J Ophthalmol. 2009 May;147(5):907-11, 911.e1. doi: 10.1016/j.ajo.2008.12.011. Epub 2009 Feb 20.
To evaluate whether artifacts caused by a stainless steel glaucoma drainage device can alter the interpretation of magnetic resonance imaging (MRI) scans of the optic nerve and brain.
Consecutive case series.
Five patients (7 eyes) with Ex-PRESS devices (Optonol Ltd, Neve Ilan, Israel) positioned at the limbus were studied. For each subject, an axial T1-weighted, axial and coronal T2-weighted with fat saturation, and whole brain proton density (PD)/T2-weighted MRI scan was obtained. Standard MRI protocol was not optimized for the imaging of patients harboring Ex-PRESS implants. The effects of the device on PD/T2 pulse sequence imaging of the optic nerve and brain were rated from 1 (optic nerve margins unidentifiable or brain details altered) to 5 (excellent visualization of the optic nerve and brain).
For optic nerve visualization, 1 optic nerve scored 2, 3 optic nerves scored 3, and 3 optic nerves scored 4 (mean, 3.3 +/- 0.8 standard deviation). For whole brain imaging, 4 patients scored 4 and 1 patient scored 5 (mean, 4.2 +/- 0.4 standard deviation).
Our data demonstrate that interpretation of MRI scans of the orbit and brain is unaffected by the artifacts caused by the Ex-PRESS shunt, whereas optic nerve imaging may be affected. We are unaware of previous reports of this finding and could find no reference to it in a computerized search using PubMed.
评估不锈钢青光眼引流装置所造成的伪影是否会改变对视神经和脑部磁共振成像(MRI)扫描结果的解读。
连续病例系列研究。
对5例(7只眼)在角膜缘植入Ex-PRESS装置(以色列内韦伊兰的Optonol有限公司生产)的患者进行研究。对每位受试者均进行了轴向T1加权、轴向和冠状面脂肪抑制T2加权以及全脑质子密度(PD)/T2加权MRI扫描。标准MRI协议未针对植入Ex-PRESS装置的患者成像进行优化。根据装置对视神经和脑部PD/T2脉冲序列成像的影响,从1分(视神经边缘无法辨认或脑部细节改变)到5分(视神经和脑部可视化效果极佳)进行评分。
对视神经可视化效果而言,1只视神经评分为2分,3只视神经评分为3分,3只视神经评分为4分(平均值为3.3±0.8标准差)。对全脑成像而言,4例患者评分为4分,1例患者评分为5分(平均值为4.2±0.4标准差)。
我们的数据表明,Ex-PRESS分流装置所造成的伪影不会影响眼眶和脑部MRI扫描结果的解读,而对视神经成像可能会有影响。我们未发现此前有关于这一发现的报告,并且在使用PubMed进行的计算机检索中也未找到相关参考文献。