Kirkham S M, Dangel M E
Department of Ophthalmology, Ohio State University, Columbus.
Ophthalmic Surg. 1991 Aug;22(8):455-61.
Due to poor biocompatibility, the success of keratoprostheses has been limited. We compared a newly-designed PMMA intracorneal keratoprosthesis, covalently coated with type-I collagen, with an identical, uncoated keratoprosthesis were retained for 15 months, the uncoated implants had more extensive adjacent corneal melting, greater inflammatory response, and more epithelial downgrowth than their collagen-coated counterparts. Electron microscopy showed that stromal collagen fibers had attached to the surface of the coated implants, but not to that of the uncoated ones. Intracorneal keratoprostheses covalently coated with type-I collagen may offer superior biocompatibility and become significantly incorporated into corneal tissues.
由于生物相容性差，角膜假体的成功率一直有限。我们比较了一种新设计的共价包被有I型胶原的聚甲基丙烯酸甲酯角膜内假体与一种相同的未包被角膜假体。在植入15个月后，未包被的植入物比其胶原包被的对应物有更广泛的相邻角膜融解、更强的炎症反应和更多的上皮内生。电子显微镜显示，基质胶原纤维附着在包被植入物的表面，而未附着在未包被植入物的表面。共价包被有I型胶原的角膜内假体可能具有更好的生物相容性，并能显著整合到角膜组织中。
