Dupont D, Gravagna P, Albinet P, Tayot J L, Romanet J P, Mouillon M, Eloy R
Laboratoires Biodomi, Saint-Just-Chaleyssin, France.
Cornea. 1989 Dec;8(4):251-8.
A new biomaterial made from human placental collagen type IV has been developed in corneal inlays for refractive keratoplasty. Eight dogs received intracorneal lenses to investigate biocompatibility. Postoperative follow-up observation of 2 years revealed that the eyes remained clear and without inflammatory reaction. Endothelial cells were unaltered. Histological and ultrastructural studies showed no signs of inflammation, ulceration, or encapsulation. No fibroblastic activity was evident at the lens stroma interface.
一种由人IV型胎盘胶原蛋白制成的新型生物材料已被开发用于屈光性角膜移植的角膜镶嵌物中。八只狗接受了角膜内晶状体植入以研究生物相容性。两年的术后随访观察表明，眼睛保持清晰且无炎症反应。内皮细胞未发生改变。组织学和超微结构研究显示没有炎症、溃疡或包囊形成的迹象。在晶状体基质界面未发现明显的成纤维细胞活性。
