Waldron L S, Ferrari B C, Power M L
Department of Biological Sciences, Macquarie University, Sydney, NSW 2109, Australia.
Exp Parasitol. 2009 Jun;122(2):124-7. doi: 10.1016/j.exppara.2009.02.006. Epub 2009 Feb 20.
Management and control of cryptosporidiosis in human requires knowledge of Cryptosporidium species contributing to human disease. Markers that are able to provide information below the species level have become important tools for source tracking. Using the hypervariable surface antigen, glycoprotein 60 (GP60), C. hominis (n=37) and C. parvum (n=32) isolates from cryptosporidiosis cases in New South Wales, Australia, were characterised. Extensive variation was observed within this locus and the isolates could be divided into 8 families and 24 different subtypes. The subtypes identified have global distributions and indicate that anthroponotic and zoonotic transmission routes contribute to sporadic human cryptosporidiosis in NSW.
人类隐孢子虫病的管理与控制需要了解导致人类疾病的隐孢子虫种类。能够在种以下水平提供信息的标志物已成为溯源的重要工具。利用高变表面抗原糖蛋白60（GP60），对来自澳大利亚新南威尔士州隐孢子虫病病例的37株人隐孢子虫（C. hominis）和32株微小隐孢子虫（C. parvum）分离株进行了特征分析。在该基因座内观察到广泛变异，这些分离株可分为8个家族和24种不同的亚型。所鉴定的亚型具有全球分布，表明人传人传播途径和人畜共患病传播途径均导致新南威尔士州散发性人类隐孢子虫病。
