Egolinskiĭ A Ia
Zh Evol Biokhim Fiziol. 1976 Jan-Feb;12(1):18-24.
Studies have been made on changes in isoenzymic spectra of lactate (LDH), malate (MDH) and sorbitol (SDH) dehydrogenases from the liver and blood serum of growing rats. In the blood serum of adult animals, 5 isoenzymes of LDH, 2 isoenzymes of MDH and 2 isoenzymes of SDH were found; in liver extracts 5, 6 and 7 fractions were observed correspondingly. During the development, relative amount of H-type isoenzymes LDH increases, whereas isoenzymic spectra of MDH and SDH undergo quantitative and qualitative changes. In ontogenesis, the specific activity of all the enzymes investigated increased. The initial level of LDH in foetal liver was higher than in adult animals, that of MDH and SDH - lower. Beginning from the 2nd week of postnatal life, the activity of LDH in the liver decreased up to the level typical of adult animals; the activity of MDH and SDH in the liver increased.
对生长中大鼠肝脏和血清中乳酸脱氢酶（LDH）、苹果酸脱氢酶（MDH）和山梨醇脱氢酶（SDH）的同工酶谱变化进行了研究。在成年动物血清中，发现了5种LDH同工酶、2种MDH同工酶和2种SDH同工酶；在肝脏提取物中，相应地观察到5、6和7个组分。在发育过程中，LDH的H型同工酶相对含量增加，而MDH和SDH的同工酶谱发生了定量和定性变化。在个体发育过程中，所有研究酶的比活性均增加。胎儿肝脏中LDH的初始水平高于成年动物，MDH和SDH的初始水平则较低。从出生后第2周开始，肝脏中LDH的活性下降至成年动物的典型水平；肝脏中MDH和SDH的活性增加。
