Yang Li Lan, Hua Qi, Liu Rong Kun, Yang Zheng
Department of Cardiology, Xuanwu Hospital of the Capital University of Medical Science, Beijing, China.
Arch Med Res. 2009 Feb;40(2):89-96. doi: 10.1016/j.arcmed.2008.11.005. Epub 2009 Jan 21.
We investigated the association between the two common polymorphisms, C1431T and Pro12Ala of PPARgamma gene, and metabolic syndrome (MS) in a Chinese population.
We included 423 subjects with MS and families without MS. Subjects were divided into three groups: MS probands and first- and second-degree relatives of probands, spouses and controls. Each group was then divided into two subgroups according to genotype (Pro/Pro and Pro/Ala for Pro12Ala, CC and CT + TT for 1431C/T). Anthropometric indices, fasting plasma glucose, lipid profile, Sv1 + Rv5 of electrocardiogram and single nucleotide polymorphisms were detected.
Frequencies of C1431T genotypes, but not Pro12Ala, were different among the three groups. MS patients with Pro/Ala genotype had higher fasting blood sugar (FBS) levels and Sv1 + Rv5. Controls with Ala allele had lower total cholesterol levels. In relatives, Ala carriers had higher high-density lipoprotein cholesterol (HDL-c) levels. BMI of the different groups were not significant. MS patients with T allele had higher FBS and Sv1 + Rv5. In relatives of MS subjects, T-allele carriers had lower blood uric acid, creatinine and higher HDL-c levels and Sv1 + Rv5.
C1431T, but not Pro12Ala polymorphisms, are associated with MS in a Chinese population. In MS patients, Ala allele and T allele are both associated with higher fasting blood sugar and higher left ventricular voltage. In controls, Ala carriers have lower total cholesterol. In MS relatives, Ala carriers had higher HDL-c levels and T-allele carriers had lower uric acid, creatinine and higher HDL-c levels and left ventricular voltage.
我们研究了中国人群中PPARγ基因的两个常见多态性位点C1431T和Pro12Ala与代谢综合征（MS）之间的关联。
我们纳入了423例患有MS的受试者以及未患MS的家庭。受试者被分为三组：MS先证者及其一级和二级亲属、配偶和对照组。然后根据基因型（Pro12Ala的Pro/Pro和Pro/Ala，1431C/T的CC和CT + TT）将每组再分为两个亚组。检测人体测量指标、空腹血糖、血脂谱、心电图的Sv1 + Rv5以及单核苷酸多态性。
三组之间C1431T基因型的频率不同，而Pro12Ala基因型频率无差异。具有Pro/Ala基因型的MS患者空腹血糖（FBS）水平和Sv1 + Rv5较高。携带Ala等位基因的对照组总胆固醇水平较低。在亲属中，携带Ala的个体高密度脂蛋白胆固醇（HDL-c）水平较高。不同组的体重指数无显著差异。携带T等位基因的MS患者FBS和Sv1 + Rv5较高。在MS受试者的亲属中，携带T等位基因的个体血尿酸、肌酐水平较低，HDL-c水平和Sv1 + Rv5较高。
在中国人群中，C1431T多态性而非Pro12Ala多态性与MS相关。在MS患者中，Ala等位基因和T等位基因均与较高的空腹血糖和较高的左心室电压相关。在对照组中，携带Ala的个体总胆固醇较低。在MS亲属中，携带Ala的个体HDL-c水平较高，携带T等位基因的个体尿酸、肌酐水平较低，HDL-c水平和左心室电压较高。
