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2
NMR studies of the exocyclic 1,N6-ethenodeoxyadenosine adduct (epsilon dA) opposite deoxyguanosine in a DNA duplex. Epsilon dA(syn).dG(anti) pairing at the lesion site.DNA双链中与脱氧鸟苷相对的环外1,N6-乙烯基脱氧腺苷加合物（ε-dA）的核磁共振研究。损伤位点处ε-dA（顺式）.dG（反式）配对。
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3
Solution conformation of the (-)-cis-anti-benzo[a]pyrenyl-dG adduct opposite dC in a DNA duplex: intercalation of the covalently attached BP ring into the helix with base displacement of the modified deoxyguanosine into the major groove.DNA双链中与dC相对的（-）-顺式-反式苯并[a]芘基-dG加合物的溶液构象：共价连接的BP环插入螺旋，修饰的脱氧鸟苷碱基位移至大沟。
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6
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Biochemistry. 1991 Feb 5;30(5):1403-12. doi: 10.1021/bi00219a034.
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O6-ethylguanine carcinogenic lesions in DNA: an NMR study of O6etG.C pairing in dodecanucleotide duplexes.DNA中的O6-乙基鸟嘌呤致癌性损伤：十二核苷酸双链体中O6etG.C配对的核磁共振研究
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4
Interactions of the human, rat, Saccharomyces cerevisiae and Escherichia coli 3-methyladenine-DNA glycosylases with DNA containing dIMP residues.人、大鼠、酿酒酵母和大肠杆菌的3-甲基腺嘌呤-DNA糖基化酶与含有dIMP残基的DNA的相互作用。
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DNA methylation by N-methyl-N-nitrosourea: methylation pattern changes in single- and double-stranded DNA, and in DNA with mismatched or bulged guanines.N-甲基-N-亚硝基脲诱导的DNA甲基化：单链和双链DNA以及含有错配或凸出鸟嘌呤的DNA中的甲基化模式变化
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Studies on the base pairing properties of deoxyinosine by solid phase hybridisation to oligonucleotides.通过与寡核苷酸进行固相杂交对脱氧肌苷碱基配对特性的研究。
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7
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8
Oligonucleotides containing fluorescent 2'-deoxyisoinosine: solid-phase synthesis and duplex stability.含荧光2'-脱氧异肌苷的寡核苷酸：固相合成及双链稳定性
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Right-handed and left-handed DNA: studies of B- and Z-DNA by using proton nuclear Overhauser effect and P NMR.右手螺旋和左手螺旋DNA：利用质子核Overhauser效应和磷核磁共振对B型和Z型DNA的研究
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Conformational analysis of r(CGCGCG) in aqueous solution: an A-type double helical conformation studied by two-dimensional nuclear Overhauser effect spectroscopy.水溶液中r(CGCGCG)的构象分析：通过二维核Overhauser效应光谱研究的A型双螺旋构象
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An alternative approach to deoxyoligonucleotides as hybridization probes by insertion of deoxyinosine at ambiguous codon positions.通过在模糊密码子位置插入脱氧肌苷，将脱氧寡核苷酸用作杂交探针的另一种方法。
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用于鉴定DNA中dI:dG错配碱基对结构的核磁共振研究。

NMR studies for identification of dI:dG mismatch base-pairing structure in DNA.

作者信息

Oda Y, Uesugi S, Ikehara M, Kawase Y, Ohtsuka E

机构信息

Faculty of Pharmaceutical Sciences, Osaka University, Japan.

出版信息

Nucleic Acids Res. 1991 Oct 11;19(19):5263-7. doi: 10.1093/nar/19.19.5263.

DOI:10.1093/nar/19.19.5263
PMID:1923809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC328885/
Abstract

One- and two-dimensional NMR experiments have been undertaken to investigate deoxyinosine:deoxyguanosine (dI:dG) base pairing in a self-complementary dodecadeoxyribonucleotide, d(C1-G2-C3-I4-A5-A6-T7-T8-G9-G10-G11-G12) (designated IG-12), duplex. The NMR data indicate formation of a dI(syn):dG(anti) base pair in a B-DNA helix. This unusual base pairing results in altered NOE patterns between the base protons (H8 and H2) of the I4 residue and the sugar protons of its own and the 5'-flanking C3 residues. The dI(syn):dG(anti) base pair is accommodated in the B-DNA duplex with only a subtle distortion of the local conformation. Identification of the dI:dG base pairing in this study confirms that a hypoxanthine base can form hydrogen-bonded base pairs with all of the four normal bases, C, A, T, and G, in DNA.

摘要

已开展一维和二维核磁共振实验，以研究一种自我互补的十二聚脱氧核糖核苷酸d（C1-G2-C3-I4-A5-A6-T7-T8-G9-G10-G11-G12）（命名为IG-12）双链体中的脱氧次黄苷：脱氧鸟苷（dI：dG）碱基对。核磁共振数据表明在B-DNA螺旋中形成了dI（顺式）：dG（反式）碱基对。这种不寻常的碱基对导致I4残基的碱基质子（H8和H2）与其自身以及5'-侧翼C3残基的糖质子之间的核Overhauser效应（NOE）模式发生改变。dI（顺式）：dG（反式）碱基对存在于B-DNA双链体中，只是局部构象有细微扭曲。本研究中对dI：dG碱基对的鉴定证实，次黄嘌呤碱基可与DNA中的所有四种正常碱基C、A、T和G形成氢键结合的碱基对。