Ivleva T S, Beliaeva I D
Biull Eksp Biol Med. 1979 Oct;88(10):445-7.
The number of cells with fragmented nuclei (FN) (mainly, multilobate) increased with aging of ascites hepatoma 22A (AH22A) as follows: 15 +/- 9.3% in the 6-day AH22A, 196 +/- 53% in the 14-day tumor and 453 +/- 51% in the delayed (18-day) AH22A. The basic way of FN formation was amitotic. About 150 and 170% of cells with FN in the 14- and 18-day AH22A were at the reversible resting R1 stage (or at the very long G1 period, more than 4 days). The rest of the cells, 50 and 230%, respectively, quit the mitotic cycle irreversibly and apparently undergo the involution that is faster during passage-stimulated division.
随着腹水型肝癌22A（AH22A）的老化，细胞核碎片化（FN）（主要是多叶状）的细胞数量增加，具体情况如下：6天龄的AH22A中为15±9.3%，14天龄肿瘤中为196±53%，延迟（18天）的AH22A中为453±51%。FN形成的基本方式是无丝分裂。在14天龄和18天龄的AH22A中，约150%和170%具有FN的细胞处于可逆的静止R1期（或处于非常长的G1期，超过4天）。其余细胞分别为50%和230%，不可逆地退出有丝分裂周期，显然经历了在传代刺激分裂过程中更快的退化。
