Abdullah Mohammad M, Riediger Natalie N, Chen Qilin, Zhao Zhaohui, Azordegan Nazila, Xu Zuyuan, Fischer Gabor, Othman Rgia A, Pierce Grant N, Tappia Paramjit S, Zou Jitao, Moghadasian Mohammed H
Departments of Human Nutritional Sciences, The University of Manitoba and St. Boniface General Hospital Research Centre, Winnipeg, MB, Canada.
Mol Cell Biochem. 2009 Jul;327(1-2):247-56. doi: 10.1007/s11010-009-0063-z. Epub 2009 Feb 24.
We investigated the effects of a high-fructose (HF) diet on cardiovascular risks in Sprague-Dawley rats. Twelve rats were randomly assigned to standard chow or HF diet for 20 weeks. Systolic blood pressure and circulating insulin, total cholesterol, and triacylglycerol levels were significantly higher in the HF group. Aortic sections appeared normal, but liver sections from the HF group showed lipid accretion, mild inflammation, and bile pigmentation. Liver samples from the HF group showed significantly higher total lipid levels and changes in fatty acid profile. Levels of 16:0, cis-9-18:2, cis-11-20:1, cis-13-20:1, cis-11-20:2 and 24:0 were significantly raised in the phospholipid fraction. Lower levels of cis-11-18:1, cis-9-18:2, and cis-11-20:1 and increased levels of 16:1, cis-9-18:1, and cis-13-20:1 were found in the non-esterified fatty acid fraction. HF-feeding resulted in significant reductions in plasma levels of certain inflammatory biomarkers. HF intake over time may negatively impact cardiovascular health and liver function in rats.
我们研究了高果糖（HF）饮食对斯普拉格-道利大鼠心血管风险的影响。将12只大鼠随机分为标准饲料组或HF饮食组，持续20周。HF组的收缩压、循环胰岛素、总胆固醇和三酰甘油水平显著更高。主动脉切片外观正常，但HF组的肝脏切片显示有脂质蓄积、轻度炎症和胆汁色素沉着。HF组的肝脏样本显示总脂质水平显著更高，脂肪酸谱也发生了变化。磷脂部分中16:0、顺式-9-18:2、顺式-11-20:1、顺式-13-20:1、顺式-11-20:2和24:0的水平显著升高。在非酯化脂肪酸部分中，顺式-11-18:1、顺式-9-18:2和顺式-11-20:1的水平较低，而16:1、顺式-9-18:1和顺式-13-20:1的水平升高。喂食HF导致某些炎症生物标志物的血浆水平显著降低。随着时间的推移，摄入HF可能会对大鼠的心血管健康和肝功能产生负面影响。
