基于甲基苯丙胺杂质剖析确定合成路线
[Determination of the synthetic route based on impurity profiling of methamphetamine].
作者信息
Zhang Jianxin, Zhang Daming, Han Xuguang, Yang Shiyun
机构信息
Forensic Medical examination Center of Beijing Public Security Bureau, Beijing 100085, China.
出版信息
Wei Sheng Yan Jiu. 2008 Nov;37(6):740-4.
OBJECTIVE
Impurity profiling of seized methamphetamine may play an important role in the determination of the synthetic method employed and the criminal investigations of drug traffic routes.
METHODS
A sample of methamphetamine was dissolved in buffer solution. Impurities were extracted with ethyl acetate containing four internal standards (n-decane, n-pentadecane, n-eicosane and n-octacosane) and analyzed by GC-MS.
RESULTS
These data are suggestive of ephedrine/pseudoephedrine as the main precursor of the methamphetamine samples seized during 2006-2007. Six samples of selected eight samples were synthesized via the more specific ephedrine/hydriodic acid/red phosphorus method.
CONCLUSION
Ephedrine/pseudoephedrine is common material used to synthesize methamphetamine.
目的
对查获的甲基苯丙胺进行杂质剖析，可能在确定所采用的合成方法以及毒品贩运路线的刑事调查中发挥重要作用。
方法
将一份甲基苯丙胺样品溶解于缓冲溶液中。用含有四种内标物（正癸烷、正十五烷、正二十烷和正二十八烷）的乙酸乙酯萃取杂质，并通过气相色谱 - 质谱联用仪进行分析。
结果
这些数据表明麻黄碱/伪麻黄碱是2006 - 2007年期间查获的甲基苯丙胺样品的主要前体。在选定的八个样品中，有六个样品是通过更具特异性的麻黄碱/氢碘酸/红磷法合成的。
结论
麻黄碱/伪麻黄碱是用于合成甲基苯丙胺的常见原料。
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