Improta G, Broccardo M
Institute of Pharmacology III, University La Sapienza, Rome, Italy.
Peptides. 1991 May-Jun;12(3):555-7. doi: 10.1016/0196-9781(91)90100-4.
Sauvagine (SV) powerfully inhibits gastric acid secretion by both the central and peripheral mechanisms. We examined whether adrenergic mechanisms or prostaglandin pathways might mediate the inhibitory action of SV on acid production in pylorus-ligated rats. Adrenalectomy altered the extent of the SV suppressive effect, suggesting that adrenal-derived substances participate in the action of the peptide. Blockade of adrenergic receptors by propranolol did not modify the antisecretory effect of SV, while the alpha-adrenergic antagonist, phentolamine, and the dopaminergic antagonist, haloperidol, potentiated the gastric response to the peptide. The action of SV appeared to be independent of prostaglandin pathways. We conclude that the antiacid effect of SV may be mediated by the adrenal but probably not by adrenergic or prostaglandin mechanisms.
蛙皮素（SV）可通过中枢和外周机制强烈抑制胃酸分泌。我们研究了肾上腺素能机制或前列腺素途径是否可能介导SV对幽门结扎大鼠胃酸分泌的抑制作用。肾上腺切除术改变了SV抑制作用的程度，这表明肾上腺来源的物质参与了该肽的作用。普萘洛尔阻断肾上腺素能受体并未改变SV的抗分泌作用，而α-肾上腺素能拮抗剂酚妥拉明和多巴胺能拮抗剂氟哌啶醇则增强了胃对该肽的反应。SV的作用似乎与前列腺素途径无关。我们得出结论，SV的抗酸作用可能由肾上腺介导，但可能不是由肾上腺素能或前列腺素机制介导。
