Murillo Carla, Weil Ann B, Moore George E, Kreuzer Matthias, Ko Jeff C
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
Department of Veterinary Administration, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
Animals (Basel). 2023 Feb 14;13(4):664. doi: 10.3390/ani13040664.
This study aimed to evaluate electroencephalography (EEG) and cardiovascular changes associated with propofol constant rate of infusion (CRI) anesthesia in dogs. Six dogs were each given propofol CRI to induce different anesthetic phases including induction (1 mg/kg/min for 10 min), and decremental maintenance doses of 2.4 mg per kg per min, 1.6 mg per kg per min, and 0.8 mg per kg per minute over 45 min. Processed EEG indices including patient state index (PSI), (burst) suppression ratio (SR), and spectral edge frequency (95%) were obtained continuously until the dogs recovered to sternal recumbency. The dogs were intubated and ventilated. Cardiovascular and EEG index values were compared between anesthetic phases. The PSI, SR, mean arterial blood pressure, and subjective anesthetic depth scores were highly correlated throughout anesthetic depth changes. The PSI decreased from 85.0 ± 17.3 at awake to 66.0 ± 29.0 at induction, and then sharply reduced to 19.7 ± 23.6 during maintenance and returned to 61.5 ± 19.2 at extubation. The SR increased from 15.4 ± 30.9% at induction to 70.9 ± 39.8% during maintenance and decreased to 3.4 ± 8.9% at extubation. We concluded that EEG indices can be used to aid in tracking ongoing brain state changes during propofol anesthesia in dogs.
本研究旨在评估犬异丙酚持续输注（CRI）麻醉过程中的脑电图（EEG）和心血管变化。六只犬分别接受异丙酚CRI以诱导不同的麻醉阶段，包括诱导期（1mg/kg/分钟，持续10分钟），以及在45分钟内递减维持剂量，分别为2.4mg/kg/分钟、1.6mg/kg/分钟和0.8mg/kg/分钟。持续获取包括患者状态指数（PSI）、（爆发）抑制率（SR）和频谱边缘频率（95%）在内的处理后EEG指标，直至犬恢复到胸骨卧位。犬进行气管插管并机械通气。比较不同麻醉阶段的心血管和EEG指标值。在整个麻醉深度变化过程中，PSI、SR、平均动脉血压和主观麻醉深度评分高度相关。PSI从清醒时的85.0±17.3降至诱导期的66.0±29.0，然后在维持期急剧降至19.7±23.6，拔管时恢复至61.5±19.2。SR从诱导期的15.4±30.9%增加至维持期的70.9±39.8%，拔管时降至3.4±8.9%。我们得出结论，EEG指标可用于辅助追踪犬异丙酚麻醉期间正在发生的脑状态变化。
