Klass B R, Grobbelaar A O, Rolfe K J
The RAFT Institute, Mount Vernon Hospital, Middlesex, UK.
Postgrad Med J. 2009 Jan;85(999):9-14. doi: 10.1136/pgmj.2008.069831.
Transforming growth factor beta1 (TGFbeta1) is a multifunctional cytokine known to be involved in a number of human diseases. It is believed to play an important role in wound healing and repair, as it is a key regulator of the production and remodelling of the extracellular matrix through its effect on mesenchymal cells. Over the last few years, it has become evident that the signalling pathway of TGFbeta is complex with numerous receptor-ligand interactions, intracellular pathways and a number of mechanisms, which not only control the signalling but may also decide the response to the TGFbeta signal. This review focuses on TGFbeta1 signalling and the role that TGFbeta1 plays in wound healing, repair and scarring.
转化生长因子β1（TGFβ1）是一种多功能细胞因子，已知其与多种人类疾病有关。据信它在伤口愈合和修复中起重要作用，因为它通过对间充质细胞的作用，是细胞外基质产生和重塑的关键调节因子。在过去几年中，越来越明显的是，TGFβ的信号通路很复杂，存在众多受体-配体相互作用、细胞内途径和多种机制，这些不仅控制信号传导，还可能决定对TGFβ信号的反应。本综述重点关注TGFβ1信号传导以及TGFβ1在伤口愈合、修复和瘢痕形成中的作用。
