Bernstein H S, Filly R A, Goldberg J D, Golbus M S
Department of Obstetrics, University of California, San Francisco.
Prenat Diagn. 1991 Jun;11(6):349-55. doi: 10.1002/pd.1970110603.
This paper reports our experience with 55 fetuses identified in utero to have a cystic hygroma. The outcome of fetuses with an isolated cystic hygroma, cystic hygroma with non-immune hydrops, and cystic hygroma with multiple anomalies was evaluated. Approximately two-thirds of karyotypes were aneuploid, and a strong association of septation and aneuploidy existed. Only five cases, four of which had isolated hygromas, came to term and resulted in live births. Two of these involved small non-septated lesions which resolved in utero.
