8-氨基喹啉伯氨喹对恶性疟原虫培养来源配子体的作用
Effect of the 8-aminoquinoline primaquine on culture-derived gametocytes of the malaria parasite Plasmodium falciparum.
作者信息
Lanners H N
机构信息
Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University Medical Center, New Orleans, LA 70112.
出版信息
Parasitol Res. 1991;77(6):478-81. doi: 10.1007/BF00928413.
PMID:1924253
Abstract
Gametocytes from the Honduras I/CDC clone HB-3 of Plasmodium falciparum were exposed to different concentrations of primaquine diphosphate. It could be shown that the drug acts specifically on the mitochondria of the cells by destroying their internal structure and causing these organelles to swell.
摘要
恶性疟原虫洪都拉斯I/疾病控制中心克隆株HB-3的配子体被暴露于不同浓度的磷酸伯氨喹。结果表明，该药物通过破坏细胞线粒体的内部结构并使其细胞器肿胀，从而特异性地作用于细胞的线粒体。
Zotero 插件