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[初级保健中参加法定或私人健康保险患者的抗高血压药物治疗]

[Antihypertensive pharmacotherapy of patients in primary care with either a statutory or private health insurance].

作者信息

Laux Gunter, Szecsenyi Joachim, Miksch Antje, Grün Barbara, Gutscher Andreas, Grün Barbara, Rosemann Thomas, Kühlein Thomas

机构信息

Abteilung Allgemeinmedizin und Versorgungsforschung, Universitätsklinikum Heidelberg, Heidelberg, Germany.

出版信息

Med Klin (Munich). 2009 Feb 15;104(2):108-13. doi: 10.1007/s00063-009-1028-4. Epub 2009 Feb 26.

Abstract

BACKGROUND AND PURPOSE

In Germany, hypertension has a prevalence of about 20%. Cardiovascular morbidity and mortality are closely associated with hypertension. Therefore, antihypertensive medical treatment is of crucial importance. Currently, five groups of drugs for the medical treatment of hypertension are available: diuretics, beta-receptor blockers, calcium antagonists, angiotensin-converting enzyme (ACE) inhibitors, and angiotensin II receptor blockers. Besides medical considerations for the treatment of hypertension costs of treatment and other economic aspects become more and more important. Within this article, the antihypertensive treatment of insurants of the statutory health insurance and the private health insurance is compared with regard to the medical treatment and associated costs.

METHODS

The analyzed data derive from the general practice morbidity research network CONTENT (CONTinuous morbidity registration Epidemiologic NeTwork). The implementation of this network is funded by the German Federal Ministry of Research and Education (BMBF) for a continuous registration of health-care utilization, morbidity, course of disease, and outcome parameters within primary care.

RESULTS

Altogether 4,842 patients from the participating general practitioners were regularly treated with antihypertensive drugs in 2007 and corresponding episodes were documented within electronic medical records. The proportion of insurants of the private health insurance was 7.6%. The costs of the antihypertensive medical treatment within the total sample in 2007 constituted 1.03 million Euros overall and per patient on average 212.82 Euros. Although the regarded sample of private health insurants was less morbid and the sum of defined daily doses (DDDs) within the observation period was notably lower (582.6 vs. 703.1; p < 0.0001), the annual therapy costs of the private health insurants compared to the statutory health insurants were 35.2% higher (280.29 Euros vs. 207.29 Euros; p < 0.0001). Hence, costs per DDD for antihypertensive medical treatment for private health insurants were 63.2% higher than for statutory health insurants. This refers to the great proportion of angiotensin II receptor blockers as well as the low proportion of generic drugs prescribed for private health insurants.

CONCLUSION

Antihypertensive treatment with original drugs and/or angiotensin II receptor blockers is an expensive option. Based on the actual state of knowledge it must be questioned critically whether this constitutes a superior treatment option concerning the potential for lowering high blood pressure levels and organ protection.

摘要

背景与目的

在德国,高血压患病率约为20%。心血管疾病的发病率和死亡率与高血压密切相关。因此,抗高血压药物治疗至关重要。目前,有五类药物可用于高血压的药物治疗:利尿剂、β受体阻滞剂、钙拮抗剂、血管紧张素转换酶(ACE)抑制剂和血管紧张素II受体阻滞剂。除了高血压治疗的医学考量外,治疗成本和其他经济方面变得越来越重要。在本文中,对法定医疗保险和私人医疗保险参保者的抗高血压治疗在药物治疗和相关成本方面进行了比较。

方法

分析的数据来自全科医疗发病率研究网络CONTENT(连续发病率登记流行病学网络)。该网络的实施由德国联邦教育与研究部(BMBF)资助,用于在初级医疗中持续登记医疗保健利用、发病率、病程和结局参数。

结果

2007年,共有4842名来自参与研究的全科医生的患者接受了抗高血压药物的常规治疗,相应的治疗过程记录在电子病历中。私人医疗保险参保者的比例为7.6%。2007年总样本中抗高血压药物治疗的费用总计103万欧元,平均每位患者212.82欧元。尽管所观察的私人医疗保险参保者样本病情较轻,且观察期内限定日剂量(DDD)总和明显较低(582.6对703.1;p<0.0001),但与法定医疗保险参保者相比,私人医疗保险参保者的年度治疗费用高出35.2%(280.29欧元对207.29欧元;p<0.0001)。因此,私人医疗保险参保者抗高血压药物治疗的每DDD成本比法定医疗保险参保者高出63.2%。这是由于私人医疗保险参保者使用血管紧张素II受体阻滞剂的比例较高,以及使用仿制药的比例较低。

结论

使用原研药和/或血管紧张素II受体阻滞剂进行抗高血压治疗是一种昂贵的选择。基于目前的知识水平,对于这种治疗方法在降低高血压水平和器官保护方面是否构成更优的治疗选择,必须进行严格质疑。

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