基于相位对比磁共振成像的弹性成像技术可检测离体猪主动脉壁的早期高血压变化。

Phase-contrast MRI-based elastography technique detects early hypertensive changes in ex vivo porcine aortic wall.

作者信息

Woodrum David A, Herrmann Joerg, Lerman Amir, Romano Anthony J, Lerman Lilach O, Ehman Richard L

机构信息

Radiology Department, Mayo Clinic, Rochester, Minnesota 55905, USA.

出版信息

J Magn Reson Imaging. 2009 Mar;29(3):583-7. doi: 10.1002/jmri.21702.

DOI:10.1002/jmri.21702

PMID:19243040

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2971532/

Abstract

PURPOSE

To measure the elastic properties of ex vivo porcine aortas in control and hypertensive groups using a phase contrast magnetic resonance imaging (MRI)-based elastography technique.

MATERIALS AND METHODS

Female domestic pigs were randomized to a normal control group (N; n=5) or a renovascular hypertension group (HT; n=5) for the duration of 3 months. Mean arterial pressure was significantly higher in the hypertension group than in the control group (173+/-12 vs. 115+/-11 mmHg, P<or=0.05). The animals were euthanized after 3 months of hypertension and abdominal aortas harvested. The ex vivo aortic samples were then examined using a phase-contrast MRI-based elastography technique.

RESULTS

The Young's modulus-wall thickness product, a reflection of vascular stiffness, was significantly higher in the hypertension group than in the control group (0.571+/-0.080 vs. 0.419+/-0.026, P<0.05). Histological analysis and staining confirmed increased intima-media thickness and collagen content in the hypertensive aorta, while elastin staining showed no difference.

CONCLUSION

The current study shows that MR elastography offers a method to study the physiologic changes in the arterial wall secondary to early hypertension.

摘要

目的

使用基于相位对比磁共振成像（MRI）的弹性成像技术测量对照组和高血压组离体猪主动脉的弹性特性。

材料与方法

将雌性家猪随机分为正常对照组（N；n = 5）或肾血管性高血压组（HT；n = 5），为期3个月。高血压组的平均动脉压显著高于对照组（173±12 vs. 115±11 mmHg，P≤0.05）。高血压3个月后对动物实施安乐死并采集腹主动脉。然后使用基于相位对比MRI的弹性成像技术检查离体主动脉样本。