Hai Pengfei, Zhou Yong, Liang Jinyang, Li Chiye, Wang Lihong V
J Biomed Opt. 2015;20(12):126008. doi: 10.1117/1.JBO.20.12.126008.
Characterization of blood vessel elastic properties can help in detecting thrombosis and preventing life-threatening conditions such as acute myocardial infarction or stroke. Vascular elastic photoacoustic tomography (VE-PAT) is proposed to measure blood vessel compliance in humans. Implemented on a linear-array-based photoacoustic computed tomography system, VE-PAT can quantify blood vessel compliance changes due to simulated thrombosis and occlusion. The feasibility of the VE-PAT system was first demonstrated by measuring the strains under uniaxial loading in perfused blood vessel phantoms and quantifying their compliance changes due to the simulated thrombosis. The VE-PAT system detected a decrease in the compliances of blood vessel phantoms with simulated thrombosis, which was validated by a standard compression test. The VE-PAT system was then applied to assess blood vessel compliance in a human subject. Experimental results showed a decrease in compliance when an occlusion occurred downstream from the measurement point in the blood vessels, demonstrating VE-PAT’s potential for clinical thrombosis detection.
血管弹性特性的表征有助于检测血栓形成，并预防诸如急性心肌梗死或中风等危及生命的疾病。血管弹性光声断层扫描（VE-PAT）被提议用于测量人体血管的顺应性。基于线性阵列的光声计算机断层扫描系统实现的VE-PAT，可以量化由于模拟血栓形成和闭塞导致的血管顺应性变化。VE-PAT系统的可行性首先通过测量灌注血管模型在单轴加载下的应变，并量化由于模拟血栓形成导致的顺应性变化来证明。VE-PAT系统检测到模拟血栓形成的血管模型的顺应性降低，这通过标准压缩试验得到了验证。然后将VE-PAT系统应用于评估人体受试者的血管顺应性。实验结果表明，当血管中测量点下游发生闭塞时，顺应性降低，这证明了VE-PAT在临床血栓检测中的潜力。
