流体二元脂质混合物中三相或两相终点的路径依赖性。
Path dependence of three-phase or two-phase end points in fluid binary lipid mixtures.
作者信息
Lamberson Emily R, Cambrea Lee R, Rochet Jean-Christophe, Hovis Jennifer S
机构信息
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
出版信息
J Phys Chem B. 2009 Mar 19;113(11):3431-6. doi: 10.1021/jp810326w.
Abstract
The phase behavior of anionic/zwitterionic mixtures can be controlled by tuning the charge state of the anionic lipid. In the case of dioleoylphosphatidic acid (DOPA)/dioleoylphosphatidylcholine (DOPC) mixtures, demixing occurs either when DOPA is protonated or when DOPA(2-):Ca(2+) complexes form. Herein it will be shown that the final end point, a three-phase or two-phase system, depends on the order in which the charge state is manipulated. The facile accessibility of different end points is a clear demonstration of the inherent flexibility of biological systems.
摘要
阴离子/两性离子混合物的相行为可通过调节阴离子脂质的电荷状态来控制。在二油酰磷脂酸（DOPA）/二油酰磷脂酰胆碱（DOPC）混合物的情况下，当DOPA质子化或形成DOPA(2 -):Ca(2 +)络合物时会发生相分离。本文将表明，最终终点，即三相或两相系统，取决于操纵电荷状态的顺序。不同终点的易达性清楚地证明了生物系统固有的灵活性。
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